@article{8000b798524f471998466e759fcc17ed,
title = "MULTIPLE GENETIC ALTERATIONS IN DISTAL AND PROXIMAL COLORECTAL CANCER",
abstract = "Multiple genetic alterations were investigated in colorectal cancer, including changes in DNA content, mutations in ras oncogenes, and deletions involving chromosomes 5, 17, and 18. A non-random association of deletions and mitotic abnormalities by site was seen, with both types of alterations occurring significantly more frequently in distal tumours. In contrast, the frequency of c-Ki-ras mutations did not differ between proximal and distal cancers. In addition, deletions were significantly associated with each other and with change in DNA content. The data provide strong support for the hypothesis that proximal and distal colon carcinoma might differ in the genetic mechanisms in their initiation and/or progression.",
author = "O. Delattre and Law, {D. J.} and Y. Remvikos and X. Sastre and Feinberg, {A. P.} and S. Olschwang and T. Melot and Salmon, {R. J.} and P. Validire and G. Thomas",
note = "Funding Information: We thank Prof J. F. Lacronique, Dr J. M. Lhoste, and Dr B. Dutrillaux for continued interest and help; Dr G. Goubin for providing some of the oligonucleotides; Dr D. Jagelman and Dr N. Petrelli for providing some of the tumour samples; and Dr B. Wieffenbach, Dr R. White, Dr Y. Nakamura, and Dr B. Vogelstein for providing RFLP probes. This work was supported by grants from the Ligue Nationale Contre le Cancer (comité de Paris and axe de biologie moléculaire clinique) to G. T. and from Howard Hughes Medical Institute to A. P. F; O. D. is a recipient of a grant from the LNCC comité de l{\textquoteright}Yonne.",
year = "1989",
month = aug,
day = "12",
doi = "10.1016/S0140-6736(89)90537-0",
language = "English (US)",
volume = "334",
pages = "353--356",
journal = "The Lancet",
issn = "0140-6736",
publisher = "Elsevier Limited",
number = "8659",
}