Multiple genetic abnormalities of 11p15 in Wilms' tumor

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Wilms' tumor has served as a model of multi pie genetic alterations in childhood cancer. This review summarizes work in our laboratory identifying several of these alterations. These include the localization to 11p15 of an embryonal tumor suppressor gene and at least one gene for Beckwith-Wiedemann syndrome, which predisposes to Wilms' tumor; as well as a novel mutational mechanism in man, loss of imprinting.

Original languageEnglish (US)
Pages (from-to)484-489
Number of pages6
JournalMedical and Pediatric Oncology
Issue number5
StatePublished - Nov 1996

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Cancer Research


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