Multiple carcinomas and intraepithelial neoplasms in a case of familial pancreatic cancer: Rapid morphological changes in the pancreatic cyst and pathological lesions undetected by clinical images

Hiroyuki Matsubayashi, Kenji Notohara, Ralph H. Hruban, Tatsunori Satoh, Junichi Kaneko, Junya Sato, Hirotoshi Ishiwatari, Ryo Ashida, Katsuhiko Uesaka, Yoshimi Kiyozumi, Hiroyuki Ono

Research output: Contribution to journalArticle


A 69-year-old woman with a family history of pancreatic cancer was referred because of imaging changes of a pancreas cyst. Magnetic resonance cholangiopancreatography showed a faintly dilated main pancreatic duct and a pancreas body cyst that had changed rapidly over the past year. Computed tomography demonstrated an emerging enhancing lesion in the pancreatic cyst. Endoscopic ultrasonography revealed an irregular-margined, heterogeneous-echoic pancreatic mass, without findings of early chronic pancreatitis. She underwent distal pancreatectomy. A histologic examination of the resected specimen revealed invasive adenocarcinoma with numerous multicentric foci of pancreatic intraepithelial neoplasia (PanIN), including high-grade PanIN, apparently separate from the main cancer.

Original languageEnglish (US)
Pages (from-to)1041-1046
Number of pages6
JournalInternal Medicine
Issue number8
StatePublished - Jan 1 2020



  • Cyst
  • Diagnosis
  • Familial
  • PanIN
  • Pancreatic cancer

ASJC Scopus subject areas

  • Internal Medicine

Cite this