Multiple biological markers and breast carcinoma

A preliminary study in the detection of recurrent disease after primary therapy

T. P. Waalkes, M. D. Abeloff, David S Ettinger, K. B. Woo, C. W. Gehrke, J. E. Mrochek

Research output: Contribution to journalArticle

Abstract

The use of a selected group of biological markers in breast cancer patients who are disease free but at risk of relapse after mastectomy has potential for detecting recurrent tumor before there is clinical evidence. In this preliminary study, multiple materials were serially analyzed in the body fluids of patients without overt tumor but receiving adjuvant chemotherapy because of positive axillary nodes at surgery. The total frequency of elevated levels was determined and compared for those patients who remained disease free, for those who subsequently relapsed, and for a third group of patients with proven metastases. Frequency of elevation was directly proportional to increasing disease. Although differences in the relative frequency of individual materials was observed, the same trends with increasing tumor burden were found. The results suggest that the serial measurement of biological markers has potential for indicating the presence of occult disease. A nucleus of biological markers to be considered should include carcinoembryonic antigen, urinary hydroxyproline/creatinine ratio for bone lesions, and γ-glutamyltranspeptidase for liver involvement.

Original languageEnglish (US)
Pages (from-to)9-19
Number of pages11
JournalJournal of Surgical Oncology
Volume18
Issue number1
DOIs
StatePublished - 1981

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Biomarkers
Breast Neoplasms
Carcinoembryonic Antigen
Hydroxyproline
Mastectomy
Body Fluids
Therapeutics
Adjuvant Chemotherapy
Tumor Burden
Creatinine
Neoplasms
Neoplasm Metastasis
Bone and Bones
Recurrence
Liver

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Multiple biological markers and breast carcinoma : A preliminary study in the detection of recurrent disease after primary therapy. / Waalkes, T. P.; Abeloff, M. D.; Ettinger, David S; Woo, K. B.; Gehrke, C. W.; Mrochek, J. E.

In: Journal of Surgical Oncology, Vol. 18, No. 1, 1981, p. 9-19.

Research output: Contribution to journalArticle

Waalkes, T. P. ; Abeloff, M. D. ; Ettinger, David S ; Woo, K. B. ; Gehrke, C. W. ; Mrochek, J. E. / Multiple biological markers and breast carcinoma : A preliminary study in the detection of recurrent disease after primary therapy. In: Journal of Surgical Oncology. 1981 ; Vol. 18, No. 1. pp. 9-19.
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