Multiple biologic activities of a cloned inducer T-cell population

G. Nabel, J. S. Greenberger, M. A. Sakakeeny, H. Cantor

Research output: Contribution to journalArticle

Abstract

The mouse T-cell clone Ly1+2-/9, belonging to the Ly1 set, displays the following functions in vitro: (i) augmentation of immunoglobulin output by B cells; (ii) stimulation of bone marrow cells to produce colonies composed of granulocytes, macrophages, or both; and (iii) proliferative stimulation of T-cell clones belonging to other Ly sets. These functions are induced by Ly1+2-/9 cells themselves and by supernatants of Ly1+2-/9 cultures and are not evinced by tested clones belonging to other Ly sets. The agent or agents responsible for colony formation and for B-cell stimulation had an apparent molecular weight of 45,000-50,000 and could not be physically separated. The T-cell stimulating agents(s) had an apparent molecular weight of 30,000 and could be separated from the agent(s) that acts upon colony formation and B cells. Thus, clone Ly1+2-/9 produces at least two soluble products that induce or augment activities of at least three other differently programmed cell sets.

Original languageEnglish (US)
Pages (from-to)1157-1161
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume78
Issue number2 II
StatePublished - 1981
Externally publishedYes

ASJC Scopus subject areas

  • General
  • Genetics

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