Multiple and surprising new functions for emerin, a nuclear membrane protein

Luiza Bengtsson, Katherine Lee Wilson

Research output: Contribution to journalArticle

Abstract

Emerin is an integral protein of the nuclear inner membrane. Emerin is not essential, but its loss of function causes Emery-Dreifuss muscular dystrophy. We summarize significant recent progress in understanding emerin, which was previously known to interact with barrier-to-autointegration factor and lamins. New partners include transcription repressors, an mRNA splicing regulator, a nuclear membrane protein named nesprin, nuclear myosin I and F-actin. These interactors imply multiple roles for emerin in the nucleus, some of which overlap with related LEM-domain proteins.

Original languageEnglish (US)
Pages (from-to)73-79
Number of pages7
JournalCurrent Opinion in Cell Biology
Volume16
Issue number1
DOIs
StatePublished - Feb 2004

Fingerprint

Nuclear Envelope
Nuclear Proteins
Membrane Proteins
Emery-Dreifuss Muscular Dystrophy
Myosin Type I
Lamins
Actins
Messenger RNA
emerin
Proteins

Keywords

  • ∼40-residue folded motif shared by LAP2, emerin and MAN1
  • (nuclear) inner membrane
  • BAF
  • Barrier-to-autointegration factor
  • EDMD
  • Emery-Dreifuss muscular dystrophy
  • Fluorescence recovery after photobleaching
  • FRAP
  • GCL
  • Germ-cell-less
  • IM
  • LEM-domain
  • MEF

ASJC Scopus subject areas

  • Cell Biology

Cite this

Multiple and surprising new functions for emerin, a nuclear membrane protein. / Bengtsson, Luiza; Wilson, Katherine Lee.

In: Current Opinion in Cell Biology, Vol. 16, No. 1, 02.2004, p. 73-79.

Research output: Contribution to journalArticle

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