Multiperson use of syringes among injection drug users in a needle exchange program: A gene-based molecular epidemiologic analysis

Sadeep Shrestha, Michael W. Smith, Karl W. Broman, Homayoon Farzadegan, David Vlahov, Steffanie A. Strathdee

Research output: Contribution to journalArticle

Abstract

Syringe-sharing behaviors among injection drug users (IDUs) are typically based on self-reports and subject to socially desirable responding. We used 3 short tandem repeat (STR) genetic biomarkers to detect sharing in 2512 syringes exchanged by 315 IDUs in the Baltimore needle exchange program (NEP; 738 person-visits). Demographic characteristics as well as direct and indirect needle-sharing behaviors corresponding to the closest AIDS Link to Intravenous Experience (ALIVE) study visits were examined for association with multiperson use (MPU) of syringes. Overall, 56% of the syringes exchanged at the Baltimore NEP had evidence of MPU. Less MPU of syringes (48% vs. 71%; P <0.0001) was seen with more rapid syringe turnaround (

Original languageEnglish (US)
Pages (from-to)335-343
Number of pages9
JournalJournal of Acquired Immune Deficiency Syndromes
Volume43
Issue number3
DOIs
StatePublished - Nov 2006

Fingerprint

Needle-Exchange Programs
Syringes
Drug Users
Injections
Needle Sharing
Baltimore
Genes
Microsatellite Repeats
Self Report
Acquired Immunodeficiency Syndrome
Biomarkers
Demography

Keywords

  • Genetic biomarkers
  • Needle circulation theory
  • Needle exchange program
  • Syringe sharing
  • Syringe-sharing risk factors

ASJC Scopus subject areas

  • Virology
  • Immunology

Cite this

Multiperson use of syringes among injection drug users in a needle exchange program : A gene-based molecular epidemiologic analysis. / Shrestha, Sadeep; Smith, Michael W.; Broman, Karl W.; Farzadegan, Homayoon; Vlahov, David; Strathdee, Steffanie A.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 43, No. 3, 11.2006, p. 335-343.

Research output: Contribution to journalArticle

Shrestha, Sadeep ; Smith, Michael W. ; Broman, Karl W. ; Farzadegan, Homayoon ; Vlahov, David ; Strathdee, Steffanie A. / Multiperson use of syringes among injection drug users in a needle exchange program : A gene-based molecular epidemiologic analysis. In: Journal of Acquired Immune Deficiency Syndromes. 2006 ; Vol. 43, No. 3. pp. 335-343.
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