Multiparametric radiomics methods for breast cancer tissue characterization using radiological imaging

Vishwa S. Parekh, Michael A. Jacobs

Research output: Contribution to journalArticlepeer-review


Background and purpose: Multiparametric radiological imaging is vital for detection, characterization, and diagnosis of many different diseases. Radiomics provide quantitative metrics from radiological imaging that may infer potential biological meaning of the underlying tissue. However, current methods are limited to regions of interest extracted from a single imaging parameter or modality, which limits the amount of information available within the data. This limitation can directly affect the integration and applicable scope of radiomics into different clinical settings, since single image radiomics are not capable of capturing the true underlying tissue characteristics in the multiparametric radiological imaging space. To that end, we developed a multiparametric imaging radiomic (mpRad) framework for extraction of first and second order radiomic features from multiparametric radiological datasets. Methods: We developed five different radiomic techniques that extract different aspects of the inter-voxel and inter-parametric relationships within the high-dimensional multiparametric magnetic resonance imaging breast datasets. Our patient cohort consisted of 138 breast patients, where, 97 patients had malignant lesions and 41 patients had benign lesions. Sensitivity, specificity, receiver operating characteristic (ROC) and areas under the curve (AUC) analysis were performed to assess diagnostic performance of the mpRad parameters. Statistical significance was set at p < 0.05. Results: The mpRad features successfully classified malignant from benign breast lesions with excellent sensitivity and specificity of 82.5% and 80.5%, respectively, with Area Under the receiver operating characteristic Curve (AUC) of 0.87 (0.81–0.93). mpRad provided a 9–28% increase in AUC metrics over single radiomic parameters. Conclusions: We have introduced the mpRad framework that extends radiomic analysis from single images to multiparametric datasets for better characterization of the underlying tissue biology.

Original languageEnglish (US)
Pages (from-to)407-421
Number of pages15
JournalBreast Cancer Research and Treatment
Issue number2
StatePublished - Apr 1 2020


  • ADC
  • Breast cancer
  • Diffusion
  • Entropy
  • Gray-level co-occurrence matrix (GLCM)
  • Informatics
  • Machine learning
  • Magnetic resonance imaging
  • Multiparametric imaging
  • Radiomics
  • Texture

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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