Multiparametric MRI tissue characterization in clinical stroke with correlation to clinical outcome: Part 2

Michael A. Jacobs, Panayiotis Mitsias, Hamid Soltanian-Zadeh, Sunitha Santhakumar, Amir Ghanei, Rabih Hammond, Donald J. Peck, Michael Chopp, Suresh Patel

Research output: Contribution to journalArticle

Abstract

Background and Purpose - Multiparametric MRI generates different zones within the lesion that may reflect heterogeneity of tissue damage in cerebral ischemia. This study presents the application of a novel model of tissue characterization based on an angular separation between tissues obtained with the use of an objective (unsupervised) computer segmentation algorithm implementing a modified version of the Iterative Self-Organizing Data Analysis Technique (ISODATA). We test the utility of this model to identify ischemic tissue in clinical stroke. Methods - MR parameters diffusion-, T2-, and T1-weighted imaging (DWI, T2WI, and T1WI, respectively) were obtained from 10 patients at 3 time points (30 studies) after stroke: acute (≤12 hours), subacute (3 to 5 days), and chronic (3 months). The National Institutes of Health Stroke Scale (NIHSS) was measured, and volumes were obtained from the ISODATA, DWI, and T2WI maps on patients at each time point. Results - The acute (≤12 hours) multiparametric ISODATA volume was significantly correlated with the acute (≤12 hours) DWI (r=0.96, P<0.05; n=10) and chronic (3 months) T2WI volume (r=0.69, P<0.05; n=10). The ISODATA-defined tissue regions exhibited MR indices consistent with ischemic and/or infarcted tissue at each time point. The acute (≤12 hours) multiparametric ISODATA volumes were significantly correlated (r=0.82, P<0.009; n=10) with the final NIHSS score. In comparison, the acute (≤12 hours) DWI volumes were less correlated (r=0.77, P<0.05; n=10) and T2WI volume (≤12h) exhibited a marginal correlation (r=0.66, P<0.05; n=10) with the final NIHSS score. Conclusions - The integrated ISODATA approach to tissue segmentation and classification discriminated abnormal from normal tissue at each time point. The ISODATA volume was significantly correlated with the current MR standards used in the clinical setting and the 3-month clinical status of the patient.

Original languageEnglish (US)
Pages (from-to)950-957
Number of pages8
JournalStroke
Volume32
Issue number4
DOIs
StatePublished - Jan 1 2001

Keywords

  • Acute
  • Cerebral ischemia
  • Computer assisted
  • Diagnostic imaging
  • Diffusion imaging
  • Focal
  • ISODATA
  • Magnetic resonance imaging
  • Signal processing
  • Stroke
  • Stroke classification

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

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    Jacobs, M. A., Mitsias, P., Soltanian-Zadeh, H., Santhakumar, S., Ghanei, A., Hammond, R., Peck, D. J., Chopp, M., & Patel, S. (2001). Multiparametric MRI tissue characterization in clinical stroke with correlation to clinical outcome: Part 2. Stroke, 32(4), 950-957. https://doi.org/10.1161/01.STR.32.4.950