Multiparametric and multimodality functional radiological imaging for breast cancer diagnosis and early treatment response assessment

Michael Jacobs, Antonio C Wolff, Katarzyna Macura, Vered Stearns, Ronald Ouwerkerk, Riham El Khouli, David A. Bluemke, Richard Wahl

Research output: Contribution to journalArticle

Abstract

Breast cancer is the second leading cause of cancer death among US women, and the chance of a woman developing breast cancer sometime during her lifetime is one in eight. Early detection and diagnosis to allow appropriate locoregional and systemic treatment are key to improve the odds of surviving its diagnosis. Emerging data also suggest that different breast cancer subtypes (phenotypes) may respond differently to available adjuvant therapies. There is a growing understanding that not all patients benefit equally from systemic therapies, and therapeutic approaches are being increasingly personalized based on predictive biomarkers of clinical benefit. Optimal use of established and novel radiological imaging methods, such as magnetic resonance imaging and positron emission tomography, which have different biophysical mechanisms can simultaneously identify key functional parameters. These methods provide unique multiparametric radiological signatures of breast cancer, that will improve the accuracy of early diagnosis, help select appropriate therapies for early stage disease, and allow early assessment of therapeutic benefit.

Original languageEnglish (US)
Pages (from-to)40-46
Number of pages7
JournalJournal of the National Cancer Institute. Monographs
Volume2015
Issue number51
DOIs
StatePublished - May 1 2015

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Breast Neoplasms
Early Diagnosis
Therapeutics
Positron-Emission Tomography
Cause of Death
Biomarkers
Magnetic Resonance Imaging
Phenotype
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Multiparametric and multimodality functional radiological imaging for breast cancer diagnosis and early treatment response assessment. / Jacobs, Michael; Wolff, Antonio C; Macura, Katarzyna; Stearns, Vered; Ouwerkerk, Ronald; Khouli, Riham El; Bluemke, David A.; Wahl, Richard.

In: Journal of the National Cancer Institute. Monographs, Vol. 2015, No. 51, 01.05.2015, p. 40-46.

Research output: Contribution to journalArticle

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