Multiparameter extrapolation of biodistribution data between species

K. A. Lathrop, Benjamin Tsui, C. T. Chen, P. V. Harper

Research output: Contribution to journalArticle

Abstract

Values of an inaccessible biological parameter in man may be predicted from values measured in animals by correlating with a parameter accessible in both species, such as body weight, energy production, excretion rate, etc. Predicting toxic effects, from environmental chemicals, of therapeutic doses for drug administration and of radiation absorbed dose from medical and environmental radioactivity depends on the rationalization of relationships between concentration and time when scaling to humans from animal data. For example, the retention of " T c, injected intravenously as pertechnetate, reaches 10% in the mouse at about 1 d, but this level occurs in humans at about 7 d. Making a simultaneous transformation between two species for the concentration and time variables by using a method of least-squares fitting, we have derived a series of transformation factors for several species. When correlated with a biological parameter such as body weight, these factors can be used to yield predicted values that are in good agreement with measured values. This system may be used with any related variables, making it useful for predicting other types of biological data.

Original languageEnglish (US)
Pages (from-to)121-126
Number of pages6
JournalHealth Physics
Volume57
StatePublished - 1989
Externally publishedYes

Fingerprint

Extrapolation
Dosimetry
extrapolation
body weight
Animals
Body Weight
Sodium Pertechnetate Tc 99m
animals
Poisons
Radioactivity
Least-Squares Analysis
weight (mass)
dosage
excretion
rationalization
animal
Radiation
radioactivity
mice
drugs

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Epidemiology
  • Radiology Nuclear Medicine and imaging
  • Environmental Science (miscellaneous)
  • Toxicology
  • Physics and Astronomy (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Environmental Chemistry
  • Environmental Science(all)

Cite this

Lathrop, K. A., Tsui, B., Chen, C. T., & Harper, P. V. (1989). Multiparameter extrapolation of biodistribution data between species. Health Physics, 57, 121-126.

Multiparameter extrapolation of biodistribution data between species. / Lathrop, K. A.; Tsui, Benjamin; Chen, C. T.; Harper, P. V.

In: Health Physics, Vol. 57, 1989, p. 121-126.

Research output: Contribution to journalArticle

Lathrop, KA, Tsui, B, Chen, CT & Harper, PV 1989, 'Multiparameter extrapolation of biodistribution data between species', Health Physics, vol. 57, pp. 121-126.
Lathrop, K. A. ; Tsui, Benjamin ; Chen, C. T. ; Harper, P. V. / Multiparameter extrapolation of biodistribution data between species. In: Health Physics. 1989 ; Vol. 57. pp. 121-126.
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