Multinucleated foreign body giant cells in placental membrane

Todd Sheridan, Frederic B. Askin, Hongxiu Ji

Research output: Contribution to journalArticle

Abstract

We report the pathologic finding of a multinucleated foreign body giant cell reaction to squames and fetal hair in the placental membranes in a 37-week 1-day intrauterine gestation. This reaction appeared to have developed in association with repeated intrauterine procedures performed in the third trimester, including cordocentesis for fetal blood sampling, intrauterine blood transfusion, and amnioreduction for polyhydramnios. This type of reaction most likely was directed to prolonged amniotic fluid leakage that occurred spontaneously or after intrauterine procedures in the second half of the second trimester and the third trimester. Careful examination of the placental membranes and recognition of the foreign body giant cell reaction may provide etiologic insight in cases of unexplained oligohydramnios.

Original languageEnglish (US)
Pages (from-to)493-496
Number of pages4
JournalPediatric and Developmental Pathology
Volume8
Issue number4
DOIs
StatePublished - Aug 1 2005

Keywords

  • Amniotic fluid leakage
  • Foreign body
  • Giant cell
  • Immunostaining
  • Intrauterine transfusion
  • Placental membrane

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine

Fingerprint Dive into the research topics of 'Multinucleated foreign body giant cells in placental membrane'. Together they form a unique fingerprint.

  • Cite this