Multimodality treatment of patients with advanced ovarian carcinoma

Jose L. Pino y Torres, Dean S. Bross, Enrique Hernandez, Neil Rosenshein, Jerry L. Klein, David S. Ettinger, Peter K. Leichner, Stanley E. Order

Research output: Contribution to journalArticlepeer-review


A multimodality treatment program bas been applied to ovarian carcinoma at the Johns Hopkins Hospital since August 1975. Forty-nine patients were subdivided into 23 patients with maximally resected Stage III micrometastatic, and 26 patients with significant retained disease, 20 with Stage III macrometastatic and 6 with Stage IV. After initial pilot studies, those patients with minimally retained disease entered a randomized prospective study. Antiovarian antiserum was used in one arm of the study; in both study arms colloidal P-32, delayed split whole abdominal irradiation, and maintenance melphalan were used. For the 23 patients with micrometastatic disease the cumulative survival and survival without evidence of disease at four years is 78 and 34% respectively. Twenty-six patients with macrometastatic disease were treated with or without intraperitoneal antiserum and multiagent chemotherapy; their cumulative one year survival is 50%. The lack of significant toxicity of intraperitoneal antiovarian antiserum and the results of multimodality therapy indicate the feasibility of this therapeutic approach to further improve ovarian cancer therapy.

Original languageEnglish (US)
Pages (from-to)1671-1677
Number of pages7
JournalInternational journal of radiation oncology, biology, physics
Issue number10
StatePublished - Oct 1982


  • Abdominal irradiation
  • Immunotherapy
  • Ovarian cancer
  • P-32
  • Tc-99

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research


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