Multimodality Treatment and Timing for Rectal Cancer in Hereditary Colorectal Cancer Patients

Aram N. Demirjian, Jonathan Efron

Research output: Contribution to journalArticle

Abstract

The management of rectal cancer is complex enough in itself but even more complicated in the setting of a hereditary cancer syndrome. Although the cancer treatment as such is similar to the one in sporadic cancer and based on cancer stage, tumor location, the patient's overall presentation and condition, the presence of an underlying disease raises additional concerns about functional aspects and the risk of metachronous lesions. We reviewed the role of multimodality treatment and the timing and extent of the planned surgeries. Rectal cancer in the setting of hereditary cancer syndromes (eg, hereditary nonpolyposis colorectal cancer, familial adenomatous polyposis) is not genuinely handled with a different approach, except when an ileal pouch anal anastomosis is planned as the neo-adjuvant modality should always be chosen to avoid the detrimental effect of radiation on an ileal pouch.

Original languageEnglish (US)
Pages (from-to)137-140
Number of pages4
JournalSeminars in Colon and Rectal Surgery
Volume22
Issue number2
DOIs
StatePublished - Jun 2011

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Rectal Neoplasms
Colorectal Neoplasms
Hereditary Neoplastic Syndromes
Colonic Pouches
Neoplasms
Hereditary Nonpolyposis Colorectal Neoplasms
Adenomatous Polyposis Coli
Radiation Effects
Therapeutics

ASJC Scopus subject areas

  • Gastroenterology
  • Surgery

Cite this

Multimodality Treatment and Timing for Rectal Cancer in Hereditary Colorectal Cancer Patients. / Demirjian, Aram N.; Efron, Jonathan.

In: Seminars in Colon and Rectal Surgery, Vol. 22, No. 2, 06.2011, p. 137-140.

Research output: Contribution to journalArticle

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