Multimodal MRI characterization of experimental subarachnoid hemorrhage

Y. Sun, Q. Shen, L. T. Watts, E. R. Muir, S. Huang, G. Y. Yang, Jose Suarez, T. Q. Duong

Research output: Contribution to journalArticle

Abstract

Subarachnoid hemorrhage (SAH) is associated with significant morbidity and mortality. We implemented an in-scanner rat model of mild SAH in which blood or vehicle was injected into the cistern magna, and applied multimodal MRI to study the brain prior to, immediately after (5min to 4h), and upto 7days after SAH. Vehicle injection did not change arterial lumen diameter, apparent diffusion coefficient (ADC), T2, venous signal, vascular reactivity to hypercapnia, or foot-fault scores, but mildly reduce cerebral blood flow (CBF) up to 4h, and open-field activity up to 7days post injection. By contrast, blood injection caused: (i) vasospasm 30min after SAH but not thereafter, (ii) venous abnormalities at 3h and 2days, delayed relative to vasospasm, (iii) reduced basal CBF and to hypercapnia 1-4h but not thereafter, (iv) reduced ADC immediately after SAH but no ADC and T2 changes on days 2 and 7, and (v) reduced open-field activities in both SAH and vehicle animals, but no significant differences in open-field activities and foot-fault tests between groups. Mild SAH exhibited transient and mild hemodynamic disturbances and diffusion changes, but did not show apparent ischemic brain injury nor functional deficits.

Original languageEnglish (US)
Pages (from-to)53-62
Number of pages10
JournalNeuroscience
Volume316
DOIs
StatePublished - Mar 1 2016
Externally publishedYes

Fingerprint

Subarachnoid Hemorrhage
Cerebrovascular Circulation
Hypercapnia
Injections
Foot
Brain Injuries
Blood Vessels
Hemodynamics
Morbidity
Mortality
Brain

Keywords

  • Cerebral ischemia
  • Magnetic resonance imaging
  • Subarachnoid hemorrhage

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Sun, Y., Shen, Q., Watts, L. T., Muir, E. R., Huang, S., Yang, G. Y., ... Duong, T. Q. (2016). Multimodal MRI characterization of experimental subarachnoid hemorrhage. Neuroscience, 316, 53-62. https://doi.org/10.1016/j.neuroscience.2015.12.027

Multimodal MRI characterization of experimental subarachnoid hemorrhage. / Sun, Y.; Shen, Q.; Watts, L. T.; Muir, E. R.; Huang, S.; Yang, G. Y.; Suarez, Jose; Duong, T. Q.

In: Neuroscience, Vol. 316, 01.03.2016, p. 53-62.

Research output: Contribution to journalArticle

Sun, Y, Shen, Q, Watts, LT, Muir, ER, Huang, S, Yang, GY, Suarez, J & Duong, TQ 2016, 'Multimodal MRI characterization of experimental subarachnoid hemorrhage', Neuroscience, vol. 316, pp. 53-62. https://doi.org/10.1016/j.neuroscience.2015.12.027
Sun, Y. ; Shen, Q. ; Watts, L. T. ; Muir, E. R. ; Huang, S. ; Yang, G. Y. ; Suarez, Jose ; Duong, T. Q. / Multimodal MRI characterization of experimental subarachnoid hemorrhage. In: Neuroscience. 2016 ; Vol. 316. pp. 53-62.
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