Multimodal integration of carbon dioxide and other sensory cues drives mosquito attraction to humans

Conor McMeniman, Román A. Corfas, Benjamin J. Matthews, Scott A. Ritchie, Leslie B. Vosshall

Research output: Contribution to journalArticle

Abstract

Multiple sensory cues emanating from humans are thought to guide blood-feeding female mosquitoes to a host. To determine the relative contribution of carbon dioxide (CO2) detection to mosquito host-seeking behavior, we mutated the AaegGr3 gene, a subunit of the heteromeric CO2 receptor in Aedes aegypti mosquitoes. Gr3 mutants lack electrophysiological and behavioral responses to CO2. These mutants also fail to show CO2-evoked responses to heat and lactic acid, a human-derived attractant, suggesting that CO2 can gate responses to other sensory stimuli. Whereas attraction of Gr3 mutants to live humans in a large semi-field environment was only slightly impaired, responses to an animal host were greatly reduced in a spatial-scale-dependent manner. Synergistic integration of heat and odor cues likely drive host-seeking behavior in the absence of CO2 detection. We reveal a networked series of interactions by which multimodal integration of CO2, human odor, and heat orchestrates mosquito attraction to humans.

Original languageEnglish (US)
Pages (from-to)1060-1071
Number of pages12
JournalCell
Volume156
Issue number5
DOIs
StatePublished - Feb 27 2014
Externally publishedYes

Fingerprint

Culicidae
Carbon Dioxide
Cues
Odors
Hot Temperature
Lactic Acid
Animals
Blood
Genes
Aedes
Drive
Odorants
Host-Seeking Behavior

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Multimodal integration of carbon dioxide and other sensory cues drives mosquito attraction to humans. / McMeniman, Conor; Corfas, Román A.; Matthews, Benjamin J.; Ritchie, Scott A.; Vosshall, Leslie B.

In: Cell, Vol. 156, No. 5, 27.02.2014, p. 1060-1071.

Research output: Contribution to journalArticle

McMeniman, Conor ; Corfas, Román A. ; Matthews, Benjamin J. ; Ritchie, Scott A. ; Vosshall, Leslie B. / Multimodal integration of carbon dioxide and other sensory cues drives mosquito attraction to humans. In: Cell. 2014 ; Vol. 156, No. 5. pp. 1060-1071.
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