Multimodal actions of neural stem cells in a mouse model of als

A meta-analysis

Yang D. Teng, Susanna C. Benn, Steven N. Kalkanis, Jeremy M. Shefner, Renna C. Onario, Bin Cheng, Mahesh B. Lachyankar, Michael Marconi, Jianxue Li, Dou Yu, Inbo Han, Nicholas J Maragakis, Jeronia Lládo, Kadir Erkmen, D. Eugene Redmond, Richard L. Sidman, Serge Przedborski, Jeffrey D Rothstein, Robert H. Brown, Evan Y. Snyder

Research output: Contribution to journalArticle

Abstract

Amyotrophic lateral sclerosis (ALS) is a lethal disease characterized by the unremitting degeneration of motor neurons. Multiple processes involving motor neurons and other cell types have been implicated in its pathogenesis. Neural stem cells (NSCs) perform multiple actions within the nervous system to fulfill their functions of organogenesis and homeostasis. We test the hypothesis that transplanted, undifferentiated multipotent migratory NSCs may help to ameliorate an array of pathological mechanisms in the SOD1G93A transgenic mouse model of ALS. On the basis of a meta-analysis of 11 independent studies performed by a consortium of ALS investigators, we propose that transplanted NSCs (both mouse and human) can slow both the onset and the progression of clinical signs and prolong survival in ALS mice, particularly if regions sustaining vital functions such as respiration are rendered chimeric. The beneficial effects of transplanted NSCs seem to be mediated by a number of actions including their ability to produce trophic factors, preserve neuromuscular function, and reduce astrogliosis and inflammation. We conclude that the widespread, pleiotropic, modulatory actions exerted by transplanted NSCs may represent an accessible therapeutic application of stem cells for treating ALS and other untreatable degenerative diseases.

Original languageEnglish (US)
Article number165ra164
JournalScience Translational Medicine
Volume4
Issue number165
DOIs
StatePublished - Dec 19 2012

Fingerprint

Neural Stem Cells
Amyotrophic Lateral Sclerosis
Meta-Analysis
Motor Neurons
Organogenesis
Nervous System
Transgenic Mice
Respiration
Homeostasis
Stem Cells
Research Personnel
Inflammation
Survival

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Teng, Y. D., Benn, S. C., Kalkanis, S. N., Shefner, J. M., Onario, R. C., Cheng, B., ... Snyder, E. Y. (2012). Multimodal actions of neural stem cells in a mouse model of als: A meta-analysis. Science Translational Medicine, 4(165), [165ra164]. https://doi.org/10.1126/scitranslmed.3004579

Multimodal actions of neural stem cells in a mouse model of als : A meta-analysis. / Teng, Yang D.; Benn, Susanna C.; Kalkanis, Steven N.; Shefner, Jeremy M.; Onario, Renna C.; Cheng, Bin; Lachyankar, Mahesh B.; Marconi, Michael; Li, Jianxue; Yu, Dou; Han, Inbo; Maragakis, Nicholas J; Lládo, Jeronia; Erkmen, Kadir; Redmond, D. Eugene; Sidman, Richard L.; Przedborski, Serge; Rothstein, Jeffrey D; Brown, Robert H.; Snyder, Evan Y.

In: Science Translational Medicine, Vol. 4, No. 165, 165ra164, 19.12.2012.

Research output: Contribution to journalArticle

Teng, YD, Benn, SC, Kalkanis, SN, Shefner, JM, Onario, RC, Cheng, B, Lachyankar, MB, Marconi, M, Li, J, Yu, D, Han, I, Maragakis, NJ, Lládo, J, Erkmen, K, Redmond, DE, Sidman, RL, Przedborski, S, Rothstein, JD, Brown, RH & Snyder, EY 2012, 'Multimodal actions of neural stem cells in a mouse model of als: A meta-analysis', Science Translational Medicine, vol. 4, no. 165, 165ra164. https://doi.org/10.1126/scitranslmed.3004579
Teng YD, Benn SC, Kalkanis SN, Shefner JM, Onario RC, Cheng B et al. Multimodal actions of neural stem cells in a mouse model of als: A meta-analysis. Science Translational Medicine. 2012 Dec 19;4(165). 165ra164. https://doi.org/10.1126/scitranslmed.3004579
Teng, Yang D. ; Benn, Susanna C. ; Kalkanis, Steven N. ; Shefner, Jeremy M. ; Onario, Renna C. ; Cheng, Bin ; Lachyankar, Mahesh B. ; Marconi, Michael ; Li, Jianxue ; Yu, Dou ; Han, Inbo ; Maragakis, Nicholas J ; Lládo, Jeronia ; Erkmen, Kadir ; Redmond, D. Eugene ; Sidman, Richard L. ; Przedborski, Serge ; Rothstein, Jeffrey D ; Brown, Robert H. ; Snyder, Evan Y. / Multimodal actions of neural stem cells in a mouse model of als : A meta-analysis. In: Science Translational Medicine. 2012 ; Vol. 4, No. 165.
@article{6f26888e06704d3d8c845f5217b4c6f6,
title = "Multimodal actions of neural stem cells in a mouse model of als: A meta-analysis",
abstract = "Amyotrophic lateral sclerosis (ALS) is a lethal disease characterized by the unremitting degeneration of motor neurons. Multiple processes involving motor neurons and other cell types have been implicated in its pathogenesis. Neural stem cells (NSCs) perform multiple actions within the nervous system to fulfill their functions of organogenesis and homeostasis. We test the hypothesis that transplanted, undifferentiated multipotent migratory NSCs may help to ameliorate an array of pathological mechanisms in the SOD1G93A transgenic mouse model of ALS. On the basis of a meta-analysis of 11 independent studies performed by a consortium of ALS investigators, we propose that transplanted NSCs (both mouse and human) can slow both the onset and the progression of clinical signs and prolong survival in ALS mice, particularly if regions sustaining vital functions such as respiration are rendered chimeric. The beneficial effects of transplanted NSCs seem to be mediated by a number of actions including their ability to produce trophic factors, preserve neuromuscular function, and reduce astrogliosis and inflammation. We conclude that the widespread, pleiotropic, modulatory actions exerted by transplanted NSCs may represent an accessible therapeutic application of stem cells for treating ALS and other untreatable degenerative diseases.",
author = "Teng, {Yang D.} and Benn, {Susanna C.} and Kalkanis, {Steven N.} and Shefner, {Jeremy M.} and Onario, {Renna C.} and Bin Cheng and Lachyankar, {Mahesh B.} and Michael Marconi and Jianxue Li and Dou Yu and Inbo Han and Maragakis, {Nicholas J} and Jeronia Ll{\'a}do and Kadir Erkmen and Redmond, {D. Eugene} and Sidman, {Richard L.} and Serge Przedborski and Rothstein, {Jeffrey D} and Brown, {Robert H.} and Snyder, {Evan Y.}",
year = "2012",
month = "12",
day = "19",
doi = "10.1126/scitranslmed.3004579",
language = "English (US)",
volume = "4",
journal = "Science Translational Medicine",
issn = "1946-6234",
publisher = "American Association for the Advancement of Science",
number = "165",

}

TY - JOUR

T1 - Multimodal actions of neural stem cells in a mouse model of als

T2 - A meta-analysis

AU - Teng, Yang D.

AU - Benn, Susanna C.

AU - Kalkanis, Steven N.

AU - Shefner, Jeremy M.

AU - Onario, Renna C.

AU - Cheng, Bin

AU - Lachyankar, Mahesh B.

AU - Marconi, Michael

AU - Li, Jianxue

AU - Yu, Dou

AU - Han, Inbo

AU - Maragakis, Nicholas J

AU - Lládo, Jeronia

AU - Erkmen, Kadir

AU - Redmond, D. Eugene

AU - Sidman, Richard L.

AU - Przedborski, Serge

AU - Rothstein, Jeffrey D

AU - Brown, Robert H.

AU - Snyder, Evan Y.

PY - 2012/12/19

Y1 - 2012/12/19

N2 - Amyotrophic lateral sclerosis (ALS) is a lethal disease characterized by the unremitting degeneration of motor neurons. Multiple processes involving motor neurons and other cell types have been implicated in its pathogenesis. Neural stem cells (NSCs) perform multiple actions within the nervous system to fulfill their functions of organogenesis and homeostasis. We test the hypothesis that transplanted, undifferentiated multipotent migratory NSCs may help to ameliorate an array of pathological mechanisms in the SOD1G93A transgenic mouse model of ALS. On the basis of a meta-analysis of 11 independent studies performed by a consortium of ALS investigators, we propose that transplanted NSCs (both mouse and human) can slow both the onset and the progression of clinical signs and prolong survival in ALS mice, particularly if regions sustaining vital functions such as respiration are rendered chimeric. The beneficial effects of transplanted NSCs seem to be mediated by a number of actions including their ability to produce trophic factors, preserve neuromuscular function, and reduce astrogliosis and inflammation. We conclude that the widespread, pleiotropic, modulatory actions exerted by transplanted NSCs may represent an accessible therapeutic application of stem cells for treating ALS and other untreatable degenerative diseases.

AB - Amyotrophic lateral sclerosis (ALS) is a lethal disease characterized by the unremitting degeneration of motor neurons. Multiple processes involving motor neurons and other cell types have been implicated in its pathogenesis. Neural stem cells (NSCs) perform multiple actions within the nervous system to fulfill their functions of organogenesis and homeostasis. We test the hypothesis that transplanted, undifferentiated multipotent migratory NSCs may help to ameliorate an array of pathological mechanisms in the SOD1G93A transgenic mouse model of ALS. On the basis of a meta-analysis of 11 independent studies performed by a consortium of ALS investigators, we propose that transplanted NSCs (both mouse and human) can slow both the onset and the progression of clinical signs and prolong survival in ALS mice, particularly if regions sustaining vital functions such as respiration are rendered chimeric. The beneficial effects of transplanted NSCs seem to be mediated by a number of actions including their ability to produce trophic factors, preserve neuromuscular function, and reduce astrogliosis and inflammation. We conclude that the widespread, pleiotropic, modulatory actions exerted by transplanted NSCs may represent an accessible therapeutic application of stem cells for treating ALS and other untreatable degenerative diseases.

UR - http://www.scopus.com/inward/record.url?scp=84871497430&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84871497430&partnerID=8YFLogxK

U2 - 10.1126/scitranslmed.3004579

DO - 10.1126/scitranslmed.3004579

M3 - Article

VL - 4

JO - Science Translational Medicine

JF - Science Translational Medicine

SN - 1946-6234

IS - 165

M1 - 165ra164

ER -