Multimethod assessment of medication nonadherence and barriers in adolescents and young adults with solid organ transplants

Cyd K. Eaton, Ana M. Gutierrez-Colina, Lauren F. Quast, Rochelle Liverman, Jennifer L. Lee, Laura L. Mee, Bonney Reed-Knight, Grace Cushman, Gloria Chiang, Rene Romero, Chad Mao, Rouba Garro, Ronald L. Blount

Research output: Contribution to journalArticlepeer-review

Abstract

Objective To (a) examine levels of medication nonadherence in adolescent and young adult (AYA) solid organ transplant recipients based on AYA- and caregiver proxy-reported nonadherence to different medication types and the medication-level variability index (MLVI) for tacrolimus, and (b) examine associations of adherence barriers and AYA and caregiver emotional distress symptoms with reported nonadherence and the MLVI. Method The sample included 47 AYAs (M age ¼ 16.67 years, SD ¼ 1.74; transplant types: 25% kidney, 47% liver, 28% heart) and their caregivers (94 total participants). AYAs and caregivers reported on AYAs' adherence barriers and their own emotional functioning. Nonadherence was measured with AYA self- and caregiver proxy-report and the MLVI for tacrolimus. Results The majority of AYAs and caregivers denied nonadherence, with lower rates of nonadherence reported for antirejection medications. In contrast, 40% of AYAs' MLVI values indicated nonadherence to tacrolimus. AYAs and caregivers who verbally acknowledged nonadherence had more AYA barriers and greater caregiver emotional distress symptoms compared with those who denied nonadherence. AYAs with MLVIs indicating nonadherence had more barriers than AYAs with MLVIs indicating adherence. Conclusions Multimethod nonadherence evaluations for AYA transplant recipients should assess objective nonadherence using the MLVI, particularly in light of low reported nonadherence rates for antirejection medications. Assessments should include adherence barriers measures, given associations with the MLVI, and potentially prioritize assessing barriers over gauging nonadherence via self- or proxy-reports. Caregiver emotional distress symptoms may also be considered to provide insight into family or environmental barriers to adherence.

Original languageEnglish (US)
Pages (from-to)789-799
Number of pages11
JournalJournal of pediatric psychology
Volume43
Issue number7
DOIs
StatePublished - Aug 1 2018

Keywords

  • Adherence
  • Adolescents
  • Assessment
  • Organ transplantation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental and Educational Psychology

Fingerprint Dive into the research topics of 'Multimethod assessment of medication nonadherence and barriers in adolescents and young adults with solid organ transplants'. Together they form a unique fingerprint.

Cite this