TY - JOUR
T1 - Multilaboratory testing of antifungal combinations against a quality control isolate of Candida krusei
AU - Chaturvedi, Vishnu
AU - Ramani, Rama
AU - Ghannoum, Mahmoud A.
AU - Killian, Scott B.
AU - Holliday, Nicole
AU - Knapp, Cindy
AU - Ostrosky-Zeichner, Luis
AU - Messer, Shawn A.
AU - Pfaller, Michael A.
AU - Iqbal, Naureen J.
AU - Arthington-Skaggs, Beth A.
AU - Vazquez, Jose A.
AU - Sein, Tin
AU - Rex, John H.
AU - Walsh, Thomas J.
PY - 2008/4
Y1 - 2008/4
N2 - Candida krusei ATCC 6258 was tested by eight laboratories using 96-well plates containing checkerboard pairwise combinations of amphotericin B (AMB), posaconazole (PSC), caspofungin (CSP), and voriconazole (VRC). The methodology led to reproducible results across the laboratories. All drug combinations yielded MICs lower than the MICs of any two drugs tested singly, and combinations of AMB, PSC, CSP, and VRC were indifferent (no antagonism) by summations of fractional inhibitory concentration.
AB - Candida krusei ATCC 6258 was tested by eight laboratories using 96-well plates containing checkerboard pairwise combinations of amphotericin B (AMB), posaconazole (PSC), caspofungin (CSP), and voriconazole (VRC). The methodology led to reproducible results across the laboratories. All drug combinations yielded MICs lower than the MICs of any two drugs tested singly, and combinations of AMB, PSC, CSP, and VRC were indifferent (no antagonism) by summations of fractional inhibitory concentration.
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U2 - 10.1128/AAC.00574-07
DO - 10.1128/AAC.00574-07
M3 - Article
C2 - 18227180
AN - SCOPUS:42049112162
SN - 0066-4804
VL - 52
SP - 1500
EP - 1502
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 4
ER -