TY - JOUR
T1 - Multifunctional Theranostic Graphene Oxide Nanoflakes as MR Imaging Agents with Enhanced Photothermal and Radiosensitizing Properties
AU - Beik, Jaber
AU - Alamzadeh, Zahra
AU - Mirrahimi, Mehri
AU - Sarikhani, Abolfazl
AU - Ardakani, Tahereh Shakerian
AU - Asadi, Mohamadreza
AU - Irajirad, Rasoul
AU - Mirrahimi, Mehraban
AU - Mahabadi, Vahid Pirhajati
AU - Eslahi, Neda
AU - Bulte, Jeff W.M.
AU - Ghaznavi, Habib
AU - Shakeri-Zadeh, Ali
N1 - Funding Information:
This study was supported by funds from the Zahedan University of Medical Sciences and the Iran University of Medical Sciences.
Publisher Copyright:
© 2021 American Chemical Society.
PY - 2021/5/17
Y1 - 2021/5/17
N2 - The integration of multiple therapeutic and diagnostic functions into a single nanoplatform for image-guided cancer therapy has been an emerging trend in nanomedicine. We show here that multifunctional theranostic nanostructures consisting of superparamagnetic iron oxide (SPIO) and gold nanoparticles (AuNPs) scaffolded within graphene oxide nanoflakes (GO-SPIO-Au NFs) can be used for dual photo/radiotherapy by virtue of the near-infrared (NIR) absorbance of GO for photothermal therapy (PTT) and the Z element radiosensitization of AuNPs for enhanced radiation therapy (RT). At the same time, this nanoplatform can also be detected by magnetic resonance (MR) imaging because of the presence of SPIO NPs. Using a mouse carcinoma model, GO-SPIO-Au NF-mediated combined PTT/RT exhibited a 1.85-fold and 1.44-fold higher therapeutic efficacy compared to either NF-mediated PTT or RT alone, respectively, resulting in a complete eradication of tumors. As a sensitive multifunctional theranostic platform, GO-SPIO-Au NFs appear to be a promising nanomaterial for enhanced cancer imaging and therapy.
AB - The integration of multiple therapeutic and diagnostic functions into a single nanoplatform for image-guided cancer therapy has been an emerging trend in nanomedicine. We show here that multifunctional theranostic nanostructures consisting of superparamagnetic iron oxide (SPIO) and gold nanoparticles (AuNPs) scaffolded within graphene oxide nanoflakes (GO-SPIO-Au NFs) can be used for dual photo/radiotherapy by virtue of the near-infrared (NIR) absorbance of GO for photothermal therapy (PTT) and the Z element radiosensitization of AuNPs for enhanced radiation therapy (RT). At the same time, this nanoplatform can also be detected by magnetic resonance (MR) imaging because of the presence of SPIO NPs. Using a mouse carcinoma model, GO-SPIO-Au NF-mediated combined PTT/RT exhibited a 1.85-fold and 1.44-fold higher therapeutic efficacy compared to either NF-mediated PTT or RT alone, respectively, resulting in a complete eradication of tumors. As a sensitive multifunctional theranostic platform, GO-SPIO-Au NFs appear to be a promising nanomaterial for enhanced cancer imaging and therapy.
KW - magnetic resonance imaging
KW - multifunctional nanoparticles
KW - photothermal therapy
KW - radiation therapy
KW - theranostics
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U2 - 10.1021/acsabm.1c00104
DO - 10.1021/acsabm.1c00104
M3 - Article
C2 - 35006840
AN - SCOPUS:85106607547
SN - 2576-6422
VL - 4
SP - 4280
EP - 4291
JO - ACS Applied Bio Materials
JF - ACS Applied Bio Materials
IS - 5
ER -