Multifunctional Theranostic Graphene Oxide Nanoflakes as MR Imaging Agents with Enhanced Photothermal and Radiosensitizing Properties

Jaber Beik, Zahra Alamzadeh, Mehri Mirrahimi, Abolfazl Sarikhani, Tahereh Shakerian Ardakani, Mohamadreza Asadi, Rasoul Irajirad, Mehraban Mirrahimi, Vahid Pirhajati Mahabadi, Neda Eslahi, Jeff W.M. Bulte, Habib Ghaznavi, Ali Shakeri-Zadeh

Research output: Contribution to journalArticlepeer-review

Abstract

The integration of multiple therapeutic and diagnostic functions into a single nanoplatform for image-guided cancer therapy has been an emerging trend in nanomedicine. We show here that multifunctional theranostic nanostructures consisting of superparamagnetic iron oxide (SPIO) and gold nanoparticles (AuNPs) scaffolded within graphene oxide nanoflakes (GO-SPIO-Au NFs) can be used for dual photo/radiotherapy by virtue of the near-infrared (NIR) absorbance of GO for photothermal therapy (PTT) and the Z element radiosensitization of AuNPs for enhanced radiation therapy (RT). At the same time, this nanoplatform can also be detected by magnetic resonance (MR) imaging because of the presence of SPIO NPs. Using a mouse carcinoma model, GO-SPIO-Au NF-mediated combined PTT/RT exhibited a 1.85-fold and 1.44-fold higher therapeutic efficacy compared to either NF-mediated PTT or RT alone, respectively, resulting in a complete eradication of tumors. As a sensitive multifunctional theranostic platform, GO-SPIO-Au NFs appear to be a promising nanomaterial for enhanced cancer imaging and therapy.

Original languageEnglish (US)
Pages (from-to)4280-4291
Number of pages12
JournalACS Applied Bio Materials
Volume4
Issue number5
DOIs
StatePublished - May 17 2021

Keywords

  • magnetic resonance imaging
  • multifunctional nanoparticles
  • photothermal therapy
  • radiation therapy
  • theranostics

ASJC Scopus subject areas

  • Chemistry(all)
  • Biomaterials
  • Biomedical Engineering
  • Biochemistry, medical

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