Multifunctional chondroitin sulphate for cartilage tissue-biomaterial integration

Dong An Wang, Shyni Varghese, Blanka Sharma, Iossif Strehin, Sara Fermanian, Justin Gorham, D. Howard Fairbrother, Brett Cascio, Jennifer H. Elisseeff

Research output: Contribution to journalArticlepeer-review

Abstract

A biologically active, high-strength tissue adhesive is needed for numerous medical applications in tissue engineering and regenerative medicine. Integration of biomaterials or implants with surrounding native tissue is crucial for both immediate functionality and long-term performance of the tissue. Here, we use the biopolymer chondroitin sulphate (CS), one of the major components of cartilage extracellular matrix, to develop a novel bioadhesive that is readily applied and acts quickly. CS was chemically functionalized with methacrylate and aldehyde groups on the polysaccharide backbone to chemically bridge biomaterials and tissue proteins via a twofold covalent link. Three-dimensional hydrogels (with and without cells) bonded to articular cartilage defects. In in vitro and in vivo functional studies this approach led to mechanical stability of the hydrogel and tissue repair in cartilage defects.

Original languageEnglish (US)
Pages (from-to)385-392
Number of pages8
JournalNature Materials
Volume6
Issue number5
DOIs
StatePublished - May 2007

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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