Multifunctional capsule-in-capsules for immunoprotection and trimodal imaging

Jaeyun Kim; Dian R. Arifin; Naser Muja; Taeho Kim; Assaf A. Gilad; Heechul Kim; Aravind Arepally; Taeghwan Hyeon; Jeff W.M. Bulte

doi:10.1002/anie.201007494

Multifunctional capsule-in-capsules for immunoprotection and trimodal imaging

Jaeyun Kim, Dian R. Arifin, Naser Muja, Taeho Kim, Assaf A. Gilad, Heechul Kim, Aravind Arepally, Taeghwan Hyeon, Jeff W.M. Bulte

School of Medicine

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

(Figure Presented) The separate encapsulation of nanoparticles (NPs) and pancreatic islets in an alginate capsule-in-capsule (CIC) structure prevents the nanoparticles being toxic to the cells while housing a high payload of nanoparticles for imaging purposes (see picture). The CIC-encapsulated islets showed an improved insulin secretion over cells encapsulated in single capsules and their transplantation into diabetic mice restored normal glycemia.

Original language	English (US)
Pages (from-to)	2317-2321
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	10
DOIs	https://doi.org/10.1002/anie.201007494
State	Published - Mar 1 2011

Keywords

Capsules
Cell delivery
Imaging agents
Insulin
Nanostructures

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.201007494

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title = "Multifunctional capsule-in-capsules for immunoprotection and trimodal imaging",

abstract = "(Figure Presented) The separate encapsulation of nanoparticles (NPs) and pancreatic islets in an alginate capsule-in-capsule (CIC) structure prevents the nanoparticles being toxic to the cells while housing a high payload of nanoparticles for imaging purposes (see picture). The CIC-encapsulated islets showed an improved insulin secretion over cells encapsulated in single capsules and their transplantation into diabetic mice restored normal glycemia.",

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AU - Kim, Jaeyun

AU - Arifin, Dian R.

AU - Muja, Naser

AU - Kim, Taeho

AU - Gilad, Assaf A.

AU - Kim, Heechul

AU - Arepally, Aravind

AU - Hyeon, Taeghwan

AU - Bulte, Jeff W.M.

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AB - (Figure Presented) The separate encapsulation of nanoparticles (NPs) and pancreatic islets in an alginate capsule-in-capsule (CIC) structure prevents the nanoparticles being toxic to the cells while housing a high payload of nanoparticles for imaging purposes (see picture). The CIC-encapsulated islets showed an improved insulin secretion over cells encapsulated in single capsules and their transplantation into diabetic mice restored normal glycemia.

KW - Capsules

KW - Cell delivery

KW - Imaging agents

KW - Insulin

KW - Nanostructures

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Multifunctional capsule-in-capsules for immunoprotection and trimodal imaging

Abstract

Keywords

ASJC Scopus subject areas

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