Multifunctional capsule-in-capsules for immunoprotection and trimodal imaging

Jaeyun Kim, Dian R. Arifin, Naser Muja, Taeho Kim, Assaf A. Gilad, Heechul Kim, Aravind Arepally, Taeghwan Hyeon, Jeff W.M. Bulte

Research output: Contribution to journalArticlepeer-review

62 Scopus citations


(Figure Presented) The separate encapsulation of nanoparticles (NPs) and pancreatic islets in an alginate capsule-in-capsule (CIC) structure prevents the nanoparticles being toxic to the cells while housing a high payload of nanoparticles for imaging purposes (see picture). The CIC-encapsulated islets showed an improved insulin secretion over cells encapsulated in single capsules and their transplantation into diabetic mice restored normal glycemia.

Original languageEnglish (US)
Pages (from-to)2317-2321
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number10
StatePublished - Mar 1 2011


  • Capsules
  • Cell delivery
  • Imaging agents
  • Insulin
  • Nanostructures

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


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