Multifunction - Laser speckle blood flow and deoxy-hemoglobin saturation - Imaging of cerebrovascular response

Nan Li, Kartikeya Murari, Abhishek Rege, Peng Miao, Nitish Thakor

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A laser speckle imaging (LSI) technique, with high spatio-temporal resolution, is presented for studying cerebrovascular response to stimulation. LSI is evaluated in a rodent model of cerebrovascular activity, in a model of migraine, by eliciting functional response to brain trigeminal nerve stimulation. The specific haemodynamic response, including deoxy-hemoglobin saturation and blood flow responses in cortical vessels to the abnormal activation of the trigeminal system, are obtained from the processed LSI images. The simultaneous optical imaging methods for imaging blood flow and deoxygenation saturation changes could be of great use in basic investigation of functional brain responses in conditions such as migraine and for evaluating investigational therapeutic solutions.

Original languageEnglish (US)
Title of host publication2009 4th International IEEE/EMBS Conference on Neural Engineering, NER '09
Pages241-244
Number of pages4
DOIs
StatePublished - Oct 27 2009
Event2009 4th International IEEE/EMBS Conference on Neural Engineering, NER '09 - Antalya, Turkey
Duration: Apr 29 2009May 2 2009

Publication series

Name2009 4th International IEEE/EMBS Conference on Neural Engineering, NER '09

Other

Other2009 4th International IEEE/EMBS Conference on Neural Engineering, NER '09
CountryTurkey
CityAntalya
Period4/29/095/2/09

Keywords

  • Cerebral vascular flow
  • Deoxyhemoglobin
  • Functional imaging
  • Imaging
  • Laser speckle
  • Trigeminal nerve

ASJC Scopus subject areas

  • Biomedical Engineering
  • Clinical Neurology
  • Neuroscience(all)

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