Multifunction - Laser speckle blood flow and deoxy-hemoglobin saturation - Imaging of cerebrovascular response

Nan Li, Kartikeya Murari, Abhishek Rege, Peng Miao, Nitish V Thakor

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A laser speckle imaging (LSI) technique, with high spatio-temporal resolution, is presented for studying cerebrovascular response to stimulation. LSI is evaluated in a rodent model of cerebrovascular activity, in a model of migraine, by eliciting functional response to brain trigeminal nerve stimulation. The specific haemodynamic response, including deoxy-hemoglobin saturation and blood flow responses in cortical vessels to the abnormal activation of the trigeminal system, are obtained from the processed LSI images. The simultaneous optical imaging methods for imaging blood flow and deoxygenation saturation changes could be of great use in basic investigation of functional brain responses in conditions such as migraine and for evaluating investigational therapeutic solutions.

Original languageEnglish (US)
Title of host publication2009 4th International IEEE/EMBS Conference on Neural Engineering, NER '09
Pages241-244
Number of pages4
DOIs
StatePublished - 2009
Event2009 4th International IEEE/EMBS Conference on Neural Engineering, NER '09 - Antalya, Turkey
Duration: Apr 29 2009May 2 2009

Other

Other2009 4th International IEEE/EMBS Conference on Neural Engineering, NER '09
CountryTurkey
CityAntalya
Period4/29/095/2/09

Fingerprint

Hemoglobin
Speckle
Hemoglobins
Lasers
Blood
Migraine Disorders
Imaging techniques
Trigeminal Nerve
Optical Imaging
Brain
Rodentia
Hemodynamics
Chemical activation
Therapeutics

Keywords

  • Cerebral vascular flow
  • Deoxyhemoglobin
  • Functional imaging
  • Imaging
  • Laser speckle
  • Trigeminal nerve

ASJC Scopus subject areas

  • Biomedical Engineering
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Li, N., Murari, K., Rege, A., Miao, P., & Thakor, N. V. (2009). Multifunction - Laser speckle blood flow and deoxy-hemoglobin saturation - Imaging of cerebrovascular response. In 2009 4th International IEEE/EMBS Conference on Neural Engineering, NER '09 (pp. 241-244). [5109278] https://doi.org/10.1109/NER.2009.5109278

Multifunction - Laser speckle blood flow and deoxy-hemoglobin saturation - Imaging of cerebrovascular response. / Li, Nan; Murari, Kartikeya; Rege, Abhishek; Miao, Peng; Thakor, Nitish V.

2009 4th International IEEE/EMBS Conference on Neural Engineering, NER '09. 2009. p. 241-244 5109278.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Li, N, Murari, K, Rege, A, Miao, P & Thakor, NV 2009, Multifunction - Laser speckle blood flow and deoxy-hemoglobin saturation - Imaging of cerebrovascular response. in 2009 4th International IEEE/EMBS Conference on Neural Engineering, NER '09., 5109278, pp. 241-244, 2009 4th International IEEE/EMBS Conference on Neural Engineering, NER '09, Antalya, Turkey, 4/29/09. https://doi.org/10.1109/NER.2009.5109278
Li N, Murari K, Rege A, Miao P, Thakor NV. Multifunction - Laser speckle blood flow and deoxy-hemoglobin saturation - Imaging of cerebrovascular response. In 2009 4th International IEEE/EMBS Conference on Neural Engineering, NER '09. 2009. p. 241-244. 5109278 https://doi.org/10.1109/NER.2009.5109278
Li, Nan ; Murari, Kartikeya ; Rege, Abhishek ; Miao, Peng ; Thakor, Nitish V. / Multifunction - Laser speckle blood flow and deoxy-hemoglobin saturation - Imaging of cerebrovascular response. 2009 4th International IEEE/EMBS Conference on Neural Engineering, NER '09. 2009. pp. 241-244
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