Multifactorial Analysis of Prognostic Factors and Survival Rates Among 706 Mucosal Melanoma Patients

Chuan Liang Cui, Bin Lian, Li Zhou, Xin Song, Xiao Shi Zhang, Di Wu, Zhi Hong Chi, Lu Si, Xi Nan Sheng, Yan Kong, Bi Xia Tang, Li Li Mao, Xuan Wang, Si Ming Li, Jie Dai, Xie Qiao Yan, Xue Bai, Charles M. Balch, Jun Guo

Research output: Contribution to journalArticle

Abstract

Background: The hypothesis that mucosal melanomas from different anatomic sites would have different prognostic features and survival outcome was tested in a multifactorial analysis. Methods: Complete clinical and pathological information from 706 mucosal melanoma patients from different anatomical sites was compared for overall survival (OS) and prognostic factors. Results: Mucosal melanomas arising from different anatomical sites did not have any significant differences in OS in a multivariate analysis (p = 0.721). Among all 706 stage I–IV mucosal melanoma patients, depth of tumor invasion (p < 0.001), number of lymph node metastases (p < 0.001), and sites of distant metastases (p < 0.001) were independent prognostic factors for OS; among 543 stage I–III patients, depth of tumor invasion (p < 0.001) and number of lymph node metastases (p < 0.001) were independent prognostic factors for OS; and among 547 stage IV patients, depth of tumor invasion (p = 0.009), number of lymph node metastases (p < 0.001), and combined distant metastases and elevation of serum lactate dehydrogenase (LDH; p < 0.001) were independent prognostic factors for OS. The presence of c-KIT or BRAF mutations was not predictive of survival. Conclusions: This is the first large-scale study comparing outcomes of mucosal melanomas from different anatomic sites in a multifactorial analysis. There were no significant survival differences among mucosal melanomas arising at different sites when matched for staging and prognostic and molecular factors, thus rejecting our hypothesis. We concluded that prognostic characteristics of mucosal melanomas can be staged as a single histological group, regardless of the anatomic site of the primary tumor.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalAnnals of Surgical Oncology
DOIs
StateAccepted/In press - May 10 2018
Externally publishedYes

Fingerprint

Melanoma
Survival Rate
Survival
Neoplasm Metastasis
Lymph Nodes
Neoplasms
L-Lactate Dehydrogenase
Multivariate Analysis
Outcome Assessment (Health Care)
Mutation
Serum

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Multifactorial Analysis of Prognostic Factors and Survival Rates Among 706 Mucosal Melanoma Patients. / Cui, Chuan Liang; Lian, Bin; Zhou, Li; Song, Xin; Zhang, Xiao Shi; Wu, Di; Chi, Zhi Hong; Si, Lu; Sheng, Xi Nan; Kong, Yan; Tang, Bi Xia; Mao, Li Li; Wang, Xuan; Li, Si Ming; Dai, Jie; Yan, Xie Qiao; Bai, Xue; Balch, Charles M.; Guo, Jun.

In: Annals of Surgical Oncology, 10.05.2018, p. 1-9.

Research output: Contribution to journalArticle

Cui, CL, Lian, B, Zhou, L, Song, X, Zhang, XS, Wu, D, Chi, ZH, Si, L, Sheng, XN, Kong, Y, Tang, BX, Mao, LL, Wang, X, Li, SM, Dai, J, Yan, XQ, Bai, X, Balch, CM & Guo, J 2018, 'Multifactorial Analysis of Prognostic Factors and Survival Rates Among 706 Mucosal Melanoma Patients', Annals of Surgical Oncology, pp. 1-9. https://doi.org/10.1245/s10434-018-6503-9
Cui, Chuan Liang ; Lian, Bin ; Zhou, Li ; Song, Xin ; Zhang, Xiao Shi ; Wu, Di ; Chi, Zhi Hong ; Si, Lu ; Sheng, Xi Nan ; Kong, Yan ; Tang, Bi Xia ; Mao, Li Li ; Wang, Xuan ; Li, Si Ming ; Dai, Jie ; Yan, Xie Qiao ; Bai, Xue ; Balch, Charles M. ; Guo, Jun. / Multifactorial Analysis of Prognostic Factors and Survival Rates Among 706 Mucosal Melanoma Patients. In: Annals of Surgical Oncology. 2018 ; pp. 1-9.
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abstract = "Background: The hypothesis that mucosal melanomas from different anatomic sites would have different prognostic features and survival outcome was tested in a multifactorial analysis. Methods: Complete clinical and pathological information from 706 mucosal melanoma patients from different anatomical sites was compared for overall survival (OS) and prognostic factors. Results: Mucosal melanomas arising from different anatomical sites did not have any significant differences in OS in a multivariate analysis (p = 0.721). Among all 706 stage I–IV mucosal melanoma patients, depth of tumor invasion (p < 0.001), number of lymph node metastases (p < 0.001), and sites of distant metastases (p < 0.001) were independent prognostic factors for OS; among 543 stage I–III patients, depth of tumor invasion (p < 0.001) and number of lymph node metastases (p < 0.001) were independent prognostic factors for OS; and among 547 stage IV patients, depth of tumor invasion (p = 0.009), number of lymph node metastases (p < 0.001), and combined distant metastases and elevation of serum lactate dehydrogenase (LDH; p < 0.001) were independent prognostic factors for OS. The presence of c-KIT or BRAF mutations was not predictive of survival. Conclusions: This is the first large-scale study comparing outcomes of mucosal melanomas from different anatomic sites in a multifactorial analysis. There were no significant survival differences among mucosal melanomas arising at different sites when matched for staging and prognostic and molecular factors, thus rejecting our hypothesis. We concluded that prognostic characteristics of mucosal melanomas can be staged as a single histological group, regardless of the anatomic site of the primary tumor.",
author = "Cui, {Chuan Liang} and Bin Lian and Li Zhou and Xin Song and Zhang, {Xiao Shi} and Di Wu and Chi, {Zhi Hong} and Lu Si and Sheng, {Xi Nan} and Yan Kong and Tang, {Bi Xia} and Mao, {Li Li} and Xuan Wang and Li, {Si Ming} and Jie Dai and Yan, {Xie Qiao} and Xue Bai and Balch, {Charles M.} and Jun Guo",
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T1 - Multifactorial Analysis of Prognostic Factors and Survival Rates Among 706 Mucosal Melanoma Patients

AU - Cui, Chuan Liang

AU - Lian, Bin

AU - Zhou, Li

AU - Song, Xin

AU - Zhang, Xiao Shi

AU - Wu, Di

AU - Chi, Zhi Hong

AU - Si, Lu

AU - Sheng, Xi Nan

AU - Kong, Yan

AU - Tang, Bi Xia

AU - Mao, Li Li

AU - Wang, Xuan

AU - Li, Si Ming

AU - Dai, Jie

AU - Yan, Xie Qiao

AU - Bai, Xue

AU - Balch, Charles M.

AU - Guo, Jun

PY - 2018/5/10

Y1 - 2018/5/10

N2 - Background: The hypothesis that mucosal melanomas from different anatomic sites would have different prognostic features and survival outcome was tested in a multifactorial analysis. Methods: Complete clinical and pathological information from 706 mucosal melanoma patients from different anatomical sites was compared for overall survival (OS) and prognostic factors. Results: Mucosal melanomas arising from different anatomical sites did not have any significant differences in OS in a multivariate analysis (p = 0.721). Among all 706 stage I–IV mucosal melanoma patients, depth of tumor invasion (p < 0.001), number of lymph node metastases (p < 0.001), and sites of distant metastases (p < 0.001) were independent prognostic factors for OS; among 543 stage I–III patients, depth of tumor invasion (p < 0.001) and number of lymph node metastases (p < 0.001) were independent prognostic factors for OS; and among 547 stage IV patients, depth of tumor invasion (p = 0.009), number of lymph node metastases (p < 0.001), and combined distant metastases and elevation of serum lactate dehydrogenase (LDH; p < 0.001) were independent prognostic factors for OS. The presence of c-KIT or BRAF mutations was not predictive of survival. Conclusions: This is the first large-scale study comparing outcomes of mucosal melanomas from different anatomic sites in a multifactorial analysis. There were no significant survival differences among mucosal melanomas arising at different sites when matched for staging and prognostic and molecular factors, thus rejecting our hypothesis. We concluded that prognostic characteristics of mucosal melanomas can be staged as a single histological group, regardless of the anatomic site of the primary tumor.

AB - Background: The hypothesis that mucosal melanomas from different anatomic sites would have different prognostic features and survival outcome was tested in a multifactorial analysis. Methods: Complete clinical and pathological information from 706 mucosal melanoma patients from different anatomical sites was compared for overall survival (OS) and prognostic factors. Results: Mucosal melanomas arising from different anatomical sites did not have any significant differences in OS in a multivariate analysis (p = 0.721). Among all 706 stage I–IV mucosal melanoma patients, depth of tumor invasion (p < 0.001), number of lymph node metastases (p < 0.001), and sites of distant metastases (p < 0.001) were independent prognostic factors for OS; among 543 stage I–III patients, depth of tumor invasion (p < 0.001) and number of lymph node metastases (p < 0.001) were independent prognostic factors for OS; and among 547 stage IV patients, depth of tumor invasion (p = 0.009), number of lymph node metastases (p < 0.001), and combined distant metastases and elevation of serum lactate dehydrogenase (LDH; p < 0.001) were independent prognostic factors for OS. The presence of c-KIT or BRAF mutations was not predictive of survival. Conclusions: This is the first large-scale study comparing outcomes of mucosal melanomas from different anatomic sites in a multifactorial analysis. There were no significant survival differences among mucosal melanomas arising at different sites when matched for staging and prognostic and molecular factors, thus rejecting our hypothesis. We concluded that prognostic characteristics of mucosal melanomas can be staged as a single histological group, regardless of the anatomic site of the primary tumor.

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