Multidrug-resistant gram-negative bloodstream infections among residents of long-term care facilities

Indumathi Venkatachalam, Hsu Li Yang, Dale Fisher, David C. Lye, Ling Moi Lin, Paul Tambyah, Trish M. Perl

Research output: Contribution to journalArticle

Abstract

Objective. Prevalence of multidrug-resistant (MDR) gram-negative (GN) bacteria is increasing globally and is complicated by patient movement between acute and long-term care facilities (LTCFs). In Asia, the contribution of LTCFs as a source of MDR GN infections is poorly described. We aimed to define the association between residence in LTCFs and MDR GN bloodstream infections (BSIs). design. Secondary analysis of data from an observational cohort. setting. Two tertiary referral hospitals in Singapore, including the 1,400-bed Tan Tock Seng Hospital and the 1,600-bed Singapore General Hospital. participants. Adult patients with healthcare-onset (HCO) or hospital-onset (HO) GN BSI. methods. Patients were identified from hospital databases using standard definitions. Risk factors for both MDR GN HCO and HO BSI were analyzed using a multivariable logistic regression model. results. A total of 675 episodes of GN BSI occurred over a 31-month period. Residence in a LTCF was an independent risk factor for developing MDR GN BSI (odds ratio [OR], 5.1 [95% confidence interval (CI), 2.2-11.9]; P

Original languageEnglish (US)
Pages (from-to)519-526
Number of pages8
JournalInfection Control and Hospital Epidemiology
Volume35
Issue number5
DOIs
StatePublished - 2014

Fingerprint

Long-Term Care
Infection
Singapore
Logistic Models
Salvia miltiorrhiza
Delivery of Health Care
Gram-Negative Bacteria
Tertiary Care Centers
General Hospitals
Odds Ratio
Databases
Confidence Intervals

ASJC Scopus subject areas

  • Microbiology (medical)
  • Epidemiology
  • Infectious Diseases
  • Medicine(all)

Cite this

Venkatachalam, I., Yang, H. L., Fisher, D., Lye, D. C., Lin, L. M., Tambyah, P., & Perl, T. M. (2014). Multidrug-resistant gram-negative bloodstream infections among residents of long-term care facilities. Infection Control and Hospital Epidemiology, 35(5), 519-526. https://doi.org/10.1086/675823

Multidrug-resistant gram-negative bloodstream infections among residents of long-term care facilities. / Venkatachalam, Indumathi; Yang, Hsu Li; Fisher, Dale; Lye, David C.; Lin, Ling Moi; Tambyah, Paul; Perl, Trish M.

In: Infection Control and Hospital Epidemiology, Vol. 35, No. 5, 2014, p. 519-526.

Research output: Contribution to journalArticle

Venkatachalam, I, Yang, HL, Fisher, D, Lye, DC, Lin, LM, Tambyah, P & Perl, TM 2014, 'Multidrug-resistant gram-negative bloodstream infections among residents of long-term care facilities', Infection Control and Hospital Epidemiology, vol. 35, no. 5, pp. 519-526. https://doi.org/10.1086/675823
Venkatachalam, Indumathi ; Yang, Hsu Li ; Fisher, Dale ; Lye, David C. ; Lin, Ling Moi ; Tambyah, Paul ; Perl, Trish M. / Multidrug-resistant gram-negative bloodstream infections among residents of long-term care facilities. In: Infection Control and Hospital Epidemiology. 2014 ; Vol. 35, No. 5. pp. 519-526.
@article{c4eac7bf788e4758bd4826cc317e8285,
title = "Multidrug-resistant gram-negative bloodstream infections among residents of long-term care facilities",
abstract = "Objective. Prevalence of multidrug-resistant (MDR) gram-negative (GN) bacteria is increasing globally and is complicated by patient movement between acute and long-term care facilities (LTCFs). In Asia, the contribution of LTCFs as a source of MDR GN infections is poorly described. We aimed to define the association between residence in LTCFs and MDR GN bloodstream infections (BSIs). design. Secondary analysis of data from an observational cohort. setting. Two tertiary referral hospitals in Singapore, including the 1,400-bed Tan Tock Seng Hospital and the 1,600-bed Singapore General Hospital. participants. Adult patients with healthcare-onset (HCO) or hospital-onset (HO) GN BSI. methods. Patients were identified from hospital databases using standard definitions. Risk factors for both MDR GN HCO and HO BSI were analyzed using a multivariable logistic regression model. results. A total of 675 episodes of GN BSI occurred over a 31-month period. Residence in a LTCF was an independent risk factor for developing MDR GN BSI (odds ratio [OR], 5.1 [95{\%} confidence interval (CI), 2.2-11.9]; P",
author = "Indumathi Venkatachalam and Yang, {Hsu Li} and Dale Fisher and Lye, {David C.} and Lin, {Ling Moi} and Paul Tambyah and Perl, {Trish M.}",
year = "2014",
doi = "10.1086/675823",
language = "English (US)",
volume = "35",
pages = "519--526",
journal = "Infection Control and Hospital Epidemiology",
issn = "0899-823X",
publisher = "University of Chicago Press",
number = "5",

}

TY - JOUR

T1 - Multidrug-resistant gram-negative bloodstream infections among residents of long-term care facilities

AU - Venkatachalam, Indumathi

AU - Yang, Hsu Li

AU - Fisher, Dale

AU - Lye, David C.

AU - Lin, Ling Moi

AU - Tambyah, Paul

AU - Perl, Trish M.

PY - 2014

Y1 - 2014

N2 - Objective. Prevalence of multidrug-resistant (MDR) gram-negative (GN) bacteria is increasing globally and is complicated by patient movement between acute and long-term care facilities (LTCFs). In Asia, the contribution of LTCFs as a source of MDR GN infections is poorly described. We aimed to define the association between residence in LTCFs and MDR GN bloodstream infections (BSIs). design. Secondary analysis of data from an observational cohort. setting. Two tertiary referral hospitals in Singapore, including the 1,400-bed Tan Tock Seng Hospital and the 1,600-bed Singapore General Hospital. participants. Adult patients with healthcare-onset (HCO) or hospital-onset (HO) GN BSI. methods. Patients were identified from hospital databases using standard definitions. Risk factors for both MDR GN HCO and HO BSI were analyzed using a multivariable logistic regression model. results. A total of 675 episodes of GN BSI occurred over a 31-month period. Residence in a LTCF was an independent risk factor for developing MDR GN BSI (odds ratio [OR], 5.1 [95% confidence interval (CI), 2.2-11.9]; P

AB - Objective. Prevalence of multidrug-resistant (MDR) gram-negative (GN) bacteria is increasing globally and is complicated by patient movement between acute and long-term care facilities (LTCFs). In Asia, the contribution of LTCFs as a source of MDR GN infections is poorly described. We aimed to define the association between residence in LTCFs and MDR GN bloodstream infections (BSIs). design. Secondary analysis of data from an observational cohort. setting. Two tertiary referral hospitals in Singapore, including the 1,400-bed Tan Tock Seng Hospital and the 1,600-bed Singapore General Hospital. participants. Adult patients with healthcare-onset (HCO) or hospital-onset (HO) GN BSI. methods. Patients were identified from hospital databases using standard definitions. Risk factors for both MDR GN HCO and HO BSI were analyzed using a multivariable logistic regression model. results. A total of 675 episodes of GN BSI occurred over a 31-month period. Residence in a LTCF was an independent risk factor for developing MDR GN BSI (odds ratio [OR], 5.1 [95% confidence interval (CI), 2.2-11.9]; P

UR - http://www.scopus.com/inward/record.url?scp=84898768991&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84898768991&partnerID=8YFLogxK

U2 - 10.1086/675823

DO - 10.1086/675823

M3 - Article

C2 - 24709720

AN - SCOPUS:84898768991

VL - 35

SP - 519

EP - 526

JO - Infection Control and Hospital Epidemiology

JF - Infection Control and Hospital Epidemiology

SN - 0899-823X

IS - 5

ER -