Multidisciplinary treatment of medulloblastoma: A 5-year experience with the SIOP trial

Massimo A. Gerosa, Enzo di Stefano, Alessandro Olivi, Alessandro Carteri

Research output: Contribution to journalArticle

Abstract

A 5-year experience of the multidisciplinary treatment of pediatric medulloblastoma with the SIOP (International Society of Pediatric Oncology) trial is presented. 33 eligible patients finally reduced to a total of 30 evaluative cases were treated with major surgical resection, extensive irradiation, and combined chemotherapy (vincristine + CCNU). The overall survival rate without recurrence was encouraging, and the actuarial survival rate is satisfactory. At follow-up controls, most of the patients showed a good performance status and a promising neurological stage. However, the problem concerning quality of life remains unsolved: Morbidity and sequelae following high-dose radiotherapy and concomitant antiblastic treatment were noticeable.

Original languageEnglish (US)
Pages (from-to)107-118
Number of pages12
JournalPediatric Neurosurgery
Volume8
Issue number2
DOIs
StatePublished - Jan 1 1981

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Keywords

  • Brain neoplasms
  • Chemotherapy
  • Medulloblastoma
  • Radiotherapy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery
  • Clinical Neurology

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