Multicolor spectral karyotyping of human chromosomes

E. Schröck, S. Du Manoir, T. Veldman, B. Schoell, J. Wienberg, M. A. Ferguson-Smith, Y. Ning, D. H. Ledbetter, I. Bar-Am, D. Soenksen, Y. Garini, T. Ried

Research output: Contribution to journalArticle

Abstract

The simultaneous and unequivocal discernment of all human chromosomes in different colors would be of significant clinical and biologic importance. Whole-genome scanning by spectral karyotyping allowed instantaneous visualization of defined emission spectra for each human chromosome after fluorescence in situ hybridization. By means of computer separation (classification) of spectra, spectrally overlapping chromosome-specific DNA probes could be resolved, and all human chromosomes were simultaneously identified.

Original languageEnglish (US)
Pages (from-to)494-497
Number of pages4
JournalScience
Volume273
Issue number5274
StatePublished - Jul 26 1996
Externally publishedYes

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Spectral Karyotyping
Human Chromosomes
DNA Probes
Fluorescence In Situ Hybridization
Color
Chromosomes
Genome

ASJC Scopus subject areas

  • General

Cite this

Schröck, E., Du Manoir, S., Veldman, T., Schoell, B., Wienberg, J., Ferguson-Smith, M. A., ... Ried, T. (1996). Multicolor spectral karyotyping of human chromosomes. Science, 273(5274), 494-497.

Multicolor spectral karyotyping of human chromosomes. / Schröck, E.; Du Manoir, S.; Veldman, T.; Schoell, B.; Wienberg, J.; Ferguson-Smith, M. A.; Ning, Y.; Ledbetter, D. H.; Bar-Am, I.; Soenksen, D.; Garini, Y.; Ried, T.

In: Science, Vol. 273, No. 5274, 26.07.1996, p. 494-497.

Research output: Contribution to journalArticle

Schröck, E, Du Manoir, S, Veldman, T, Schoell, B, Wienberg, J, Ferguson-Smith, MA, Ning, Y, Ledbetter, DH, Bar-Am, I, Soenksen, D, Garini, Y & Ried, T 1996, 'Multicolor spectral karyotyping of human chromosomes', Science, vol. 273, no. 5274, pp. 494-497.
Schröck E, Du Manoir S, Veldman T, Schoell B, Wienberg J, Ferguson-Smith MA et al. Multicolor spectral karyotyping of human chromosomes. Science. 1996 Jul 26;273(5274):494-497.
Schröck, E. ; Du Manoir, S. ; Veldman, T. ; Schoell, B. ; Wienberg, J. ; Ferguson-Smith, M. A. ; Ning, Y. ; Ledbetter, D. H. ; Bar-Am, I. ; Soenksen, D. ; Garini, Y. ; Ried, T. / Multicolor spectral karyotyping of human chromosomes. In: Science. 1996 ; Vol. 273, No. 5274. pp. 494-497.
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