Multicolor spectral karyotyping of human chromosomes

E. Schröck, S. Du Manoir, T. Veldman, B. Schoell, J. Wienberg, M. A. Ferguson-Smith, Y. Ning, D. H. Ledbetter, I. Bar-Am, D. Soenksen, Y. Garini, T. Ried

Research output: Contribution to journalArticle

Abstract

The simultaneous and unequivocal discernment of all human chromosomes in different colors would be of significant clinical and biologic importance. Whole-genome scanning by spectral karyotyping allowed instantaneous visualization of defined emission spectra for each human chromosome after fluorescence in situ hybridization. By means of computer separation (classification) of spectra, spectrally overlapping chromosome-specific DNA probes could be resolved, and all human chromosomes were simultaneously identified.

Original languageEnglish (US)
Pages (from-to)494-497
Number of pages4
JournalScience
Volume273
Issue number5274
DOIs
StatePublished - Jul 26 1996

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Multicolor spectral karyotyping of human chromosomes'. Together they form a unique fingerprint.

  • Cite this

    Schröck, E., Du Manoir, S., Veldman, T., Schoell, B., Wienberg, J., Ferguson-Smith, M. A., Ning, Y., Ledbetter, D. H., Bar-Am, I., Soenksen, D., Garini, Y., & Ried, T. (1996). Multicolor spectral karyotyping of human chromosomes. Science, 273(5274), 494-497. https://doi.org/10.1126/science.273.5274.494