Multiclonal origin of polyps in Gardner syndrome

Susan H. Hsu, Gordon D. Luk, Anne J. Krush, Stanley R. Hamilton, Herbert H. Hoover

Research output: Contribution to journalArticle

Abstract

Electrophoretic analysis of glucose-6-phosphate dehydrogenase was performed on polyp tissue from three black female patients with Gardner syndrome and who are heterozygous for the A and B forms of this enzyme. Polyp tissues from the three patients displayed the AB phenotype. This finding suggests a multiclonal origin of polyps in Gardner syndrome. Studies of tumors originating from such polyps may provide information about the sequence of cellular events leading to malignant transformation.

Original languageEnglish (US)
Pages (from-to)951-953
Number of pages3
JournalScience
Volume221
Issue number4614
DOIs
StatePublished - Jan 1 1983

ASJC Scopus subject areas

  • General

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    Hsu, S. H., Luk, G. D., Krush, A. J., Hamilton, S. R., & Hoover, H. H. (1983). Multiclonal origin of polyps in Gardner syndrome. Science, 221(4614), 951-953. https://doi.org/10.1126/science.6879192