Multicenter trial of Cryotherapy for Retinopathy of Prematurity: Ophthalmological outcomes at 10 years

F. J. Elsas, M. Collins, J. Jones, J. A. Kimble, L. Kline, D. Witherspoon, A. M. Roth, B. H. Demorest, W. S. Gilbert, D. Plotsky, M. Jaafar, A. R. Pilkerton, P. A. Mercer, R. M. Siatkowski, J. Clarkson, R. A. Johnson, J. Simon, J. Zobal-Ratner, M. T. Miller, C. CroninM. Daily, L. M. Kaufman, D. Mittelman, N. Santiago, M. Shapiro, K. Skuran, P. Squires, C. Vygantas, F. D. Ellis, D. Bates, E. M. Helveston, C. C. Barr, C. H. Douglas, P. H. Fishman, G. K. Whittington, R. A. Gordon, J. G. Diamond, D. Neff, Michael X Repka, J. A. Haller, S. P. Kraft, J. Mattheu, J. D. Baker, M. T. Trese, P. J. Droste, P. Manatrey, J. Roarty, C. Gail Summers, D. K. Knobloch, J. D. Lavoie, R. C. Ramsay, T. L. Young, D. L. Phelps, H. Camarda, E. Guillet, R. Olsen, D. Tingley, N. Wood, P. Torrisi, R. Hampton, W. Merriam, J. D. Reynolds, S. Awner, E. G. Buckley, Jr Anderson M.M., M. J. Burke, J. C. Johnson, G. L. Rogers, D. L. Bremer, R. R. Fellows, A. D. Letson, R. E. McClead, M. L K McGregor, E. A. Palmer, P. Bartholomew, G. E. Quinn, G. C. Brown, R. W. Hertle, J. J. Kubacki, S. J. Menacker, D. L. Miller, D. B. Schaffer, W. Tasman, M. C. Wilson, K. P. Cheng, A. W. Biglan, J. S. Davis, M. Schramm, R. A. Saunders, E. Bluestein, S. P. Donahue, A. B. Law, R. Sinatra, S. Steele, R. Spencer, J. Arnwine, P. M. Berry, J. N. Leffler, D. R. Stager

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate outcomes at 10 years after randomization for eyes undergoing cryotherapy vs eyes serving as controls, for patients enrolled in the Multicenter Trial of Cryotherapy for Retinopathy of Prematurity (CRYO-ROP). Methods: The randomized cohort originally consisted of 291 preterm children with birth weights less than 1251 g who developed a defined threshold of ROP severity in one or both eyes. Patients with bilateral threshold ROP (n = 240) were randomly assigned to receive cryotherapy to one eye and no cryotherapy to the other eye. Those with ROP of less severity than threshold in the fellow eye ("asymmetric"; n = 51) were randomly assigned to cryotherapy or no cryotherapy in the eye with threshold ROP. Ten years later, a tester who was masked to treatment status of each eye measured distance and near visual acuity, with "unfavorable" outcome being 20/200 or worse. Patients also were evaluated by study-certified ophthalmologists who assessed ROP residua primarily in the posterior pole of the fundus, with unfavorable outcome being a posterior retinal fold or worse. Results: For the 247 children examined, both functional and structural primary outcomes showed fewer unfavorable outcomes in treated vs control eyes: 44.4% vs 62.1% (P

Original languageEnglish (US)
Pages (from-to)1110-1118
Number of pages9
JournalArchives of Ophthalmology
Volume119
Issue number8
StatePublished - 2001
Externally publishedYes

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Retinopathy of Prematurity
Cryotherapy
Multicenter Studies
Random Allocation
Birth Weight
Visual Acuity
ROP

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Elsas, F. J., Collins, M., Jones, J., Kimble, J. A., Kline, L., Witherspoon, D., ... Stager, D. R. (2001). Multicenter trial of Cryotherapy for Retinopathy of Prematurity: Ophthalmological outcomes at 10 years. Archives of Ophthalmology, 119(8), 1110-1118.

Multicenter trial of Cryotherapy for Retinopathy of Prematurity : Ophthalmological outcomes at 10 years. / Elsas, F. J.; Collins, M.; Jones, J.; Kimble, J. A.; Kline, L.; Witherspoon, D.; Roth, A. M.; Demorest, B. H.; Gilbert, W. S.; Plotsky, D.; Jaafar, M.; Pilkerton, A. R.; Mercer, P. A.; Siatkowski, R. M.; Clarkson, J.; Johnson, R. A.; Simon, J.; Zobal-Ratner, J.; Miller, M. T.; Cronin, C.; Daily, M.; Kaufman, L. M.; Mittelman, D.; Santiago, N.; Shapiro, M.; Skuran, K.; Squires, P.; Vygantas, C.; Ellis, F. D.; Bates, D.; Helveston, E. M.; Barr, C. C.; Douglas, C. H.; Fishman, P. H.; Whittington, G. K.; Gordon, R. A.; Diamond, J. G.; Neff, D.; Repka, Michael X; Haller, J. A.; Kraft, S. P.; Mattheu, J.; Baker, J. D.; Trese, M. T.; Droste, P. J.; Manatrey, P.; Roarty, J.; Gail Summers, C.; Knobloch, D. K.; Lavoie, J. D.; Ramsay, R. C.; Young, T. L.; Phelps, D. L.; Camarda, H.; Guillet, E.; Olsen, R.; Tingley, D.; Wood, N.; Torrisi, P.; Hampton, R.; Merriam, W.; Reynolds, J. D.; Awner, S.; Buckley, E. G.; Anderson M.M., Jr; Burke, M. J.; Johnson, J. C.; Rogers, G. L.; Bremer, D. L.; Fellows, R. R.; Letson, A. D.; McClead, R. E.; McGregor, M. L K; Palmer, E. A.; Bartholomew, P.; Quinn, G. E.; Brown, G. C.; Hertle, R. W.; Kubacki, J. J.; Menacker, S. J.; Miller, D. L.; Schaffer, D. B.; Tasman, W.; Wilson, M. C.; Cheng, K. P.; Biglan, A. W.; Davis, J. S.; Schramm, M.; Saunders, R. A.; Bluestein, E.; Donahue, S. P.; Law, A. B.; Sinatra, R.; Steele, S.; Spencer, R.; Arnwine, J.; Berry, P. M.; Leffler, J. N.; Stager, D. R.

In: Archives of Ophthalmology, Vol. 119, No. 8, 2001, p. 1110-1118.

Research output: Contribution to journalArticle

Elsas, FJ, Collins, M, Jones, J, Kimble, JA, Kline, L, Witherspoon, D, Roth, AM, Demorest, BH, Gilbert, WS, Plotsky, D, Jaafar, M, Pilkerton, AR, Mercer, PA, Siatkowski, RM, Clarkson, J, Johnson, RA, Simon, J, Zobal-Ratner, J, Miller, MT, Cronin, C, Daily, M, Kaufman, LM, Mittelman, D, Santiago, N, Shapiro, M, Skuran, K, Squires, P, Vygantas, C, Ellis, FD, Bates, D, Helveston, EM, Barr, CC, Douglas, CH, Fishman, PH, Whittington, GK, Gordon, RA, Diamond, JG, Neff, D, Repka, MX, Haller, JA, Kraft, SP, Mattheu, J, Baker, JD, Trese, MT, Droste, PJ, Manatrey, P, Roarty, J, Gail Summers, C, Knobloch, DK, Lavoie, JD, Ramsay, RC, Young, TL, Phelps, DL, Camarda, H, Guillet, E, Olsen, R, Tingley, D, Wood, N, Torrisi, P, Hampton, R, Merriam, W, Reynolds, JD, Awner, S, Buckley, EG, Anderson M.M., J, Burke, MJ, Johnson, JC, Rogers, GL, Bremer, DL, Fellows, RR, Letson, AD, McClead, RE, McGregor, MLK, Palmer, EA, Bartholomew, P, Quinn, GE, Brown, GC, Hertle, RW, Kubacki, JJ, Menacker, SJ, Miller, DL, Schaffer, DB, Tasman, W, Wilson, MC, Cheng, KP, Biglan, AW, Davis, JS, Schramm, M, Saunders, RA, Bluestein, E, Donahue, SP, Law, AB, Sinatra, R, Steele, S, Spencer, R, Arnwine, J, Berry, PM, Leffler, JN & Stager, DR 2001, 'Multicenter trial of Cryotherapy for Retinopathy of Prematurity: Ophthalmological outcomes at 10 years', Archives of Ophthalmology, vol. 119, no. 8, pp. 1110-1118.
Elsas FJ, Collins M, Jones J, Kimble JA, Kline L, Witherspoon D et al. Multicenter trial of Cryotherapy for Retinopathy of Prematurity: Ophthalmological outcomes at 10 years. Archives of Ophthalmology. 2001;119(8):1110-1118.
Elsas, F. J. ; Collins, M. ; Jones, J. ; Kimble, J. A. ; Kline, L. ; Witherspoon, D. ; Roth, A. M. ; Demorest, B. H. ; Gilbert, W. S. ; Plotsky, D. ; Jaafar, M. ; Pilkerton, A. R. ; Mercer, P. A. ; Siatkowski, R. M. ; Clarkson, J. ; Johnson, R. A. ; Simon, J. ; Zobal-Ratner, J. ; Miller, M. T. ; Cronin, C. ; Daily, M. ; Kaufman, L. M. ; Mittelman, D. ; Santiago, N. ; Shapiro, M. ; Skuran, K. ; Squires, P. ; Vygantas, C. ; Ellis, F. D. ; Bates, D. ; Helveston, E. M. ; Barr, C. C. ; Douglas, C. H. ; Fishman, P. H. ; Whittington, G. K. ; Gordon, R. A. ; Diamond, J. G. ; Neff, D. ; Repka, Michael X ; Haller, J. A. ; Kraft, S. P. ; Mattheu, J. ; Baker, J. D. ; Trese, M. T. ; Droste, P. J. ; Manatrey, P. ; Roarty, J. ; Gail Summers, C. ; Knobloch, D. K. ; Lavoie, J. D. ; Ramsay, R. C. ; Young, T. L. ; Phelps, D. L. ; Camarda, H. ; Guillet, E. ; Olsen, R. ; Tingley, D. ; Wood, N. ; Torrisi, P. ; Hampton, R. ; Merriam, W. ; Reynolds, J. D. ; Awner, S. ; Buckley, E. G. ; Anderson M.M., Jr ; Burke, M. J. ; Johnson, J. C. ; Rogers, G. L. ; Bremer, D. L. ; Fellows, R. R. ; Letson, A. D. ; McClead, R. E. ; McGregor, M. L K ; Palmer, E. A. ; Bartholomew, P. ; Quinn, G. E. ; Brown, G. C. ; Hertle, R. W. ; Kubacki, J. J. ; Menacker, S. J. ; Miller, D. L. ; Schaffer, D. B. ; Tasman, W. ; Wilson, M. C. ; Cheng, K. P. ; Biglan, A. W. ; Davis, J. S. ; Schramm, M. ; Saunders, R. A. ; Bluestein, E. ; Donahue, S. P. ; Law, A. B. ; Sinatra, R. ; Steele, S. ; Spencer, R. ; Arnwine, J. ; Berry, P. M. ; Leffler, J. N. ; Stager, D. R. / Multicenter trial of Cryotherapy for Retinopathy of Prematurity : Ophthalmological outcomes at 10 years. In: Archives of Ophthalmology. 2001 ; Vol. 119, No. 8. pp. 1110-1118.
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language = "English (US)",
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TY - JOUR

T1 - Multicenter trial of Cryotherapy for Retinopathy of Prematurity

T2 - Ophthalmological outcomes at 10 years

AU - Elsas, F. J.

AU - Collins, M.

AU - Jones, J.

AU - Kimble, J. A.

AU - Kline, L.

AU - Witherspoon, D.

AU - Roth, A. M.

AU - Demorest, B. H.

AU - Gilbert, W. S.

AU - Plotsky, D.

AU - Jaafar, M.

AU - Pilkerton, A. R.

AU - Mercer, P. A.

AU - Siatkowski, R. M.

AU - Clarkson, J.

AU - Johnson, R. A.

AU - Simon, J.

AU - Zobal-Ratner, J.

AU - Miller, M. T.

AU - Cronin, C.

AU - Daily, M.

AU - Kaufman, L. M.

AU - Mittelman, D.

AU - Santiago, N.

AU - Shapiro, M.

AU - Skuran, K.

AU - Squires, P.

AU - Vygantas, C.

AU - Ellis, F. D.

AU - Bates, D.

AU - Helveston, E. M.

AU - Barr, C. C.

AU - Douglas, C. H.

AU - Fishman, P. H.

AU - Whittington, G. K.

AU - Gordon, R. A.

AU - Diamond, J. G.

AU - Neff, D.

AU - Repka, Michael X

AU - Haller, J. A.

AU - Kraft, S. P.

AU - Mattheu, J.

AU - Baker, J. D.

AU - Trese, M. T.

AU - Droste, P. J.

AU - Manatrey, P.

AU - Roarty, J.

AU - Gail Summers, C.

AU - Knobloch, D. K.

AU - Lavoie, J. D.

AU - Ramsay, R. C.

AU - Young, T. L.

AU - Phelps, D. L.

AU - Camarda, H.

AU - Guillet, E.

AU - Olsen, R.

AU - Tingley, D.

AU - Wood, N.

AU - Torrisi, P.

AU - Hampton, R.

AU - Merriam, W.

AU - Reynolds, J. D.

AU - Awner, S.

AU - Buckley, E. G.

AU - Anderson M.M., Jr

AU - Burke, M. J.

AU - Johnson, J. C.

AU - Rogers, G. L.

AU - Bremer, D. L.

AU - Fellows, R. R.

AU - Letson, A. D.

AU - McClead, R. E.

AU - McGregor, M. L K

AU - Palmer, E. A.

AU - Bartholomew, P.

AU - Quinn, G. E.

AU - Brown, G. C.

AU - Hertle, R. W.

AU - Kubacki, J. J.

AU - Menacker, S. J.

AU - Miller, D. L.

AU - Schaffer, D. B.

AU - Tasman, W.

AU - Wilson, M. C.

AU - Cheng, K. P.

AU - Biglan, A. W.

AU - Davis, J. S.

AU - Schramm, M.

AU - Saunders, R. A.

AU - Bluestein, E.

AU - Donahue, S. P.

AU - Law, A. B.

AU - Sinatra, R.

AU - Steele, S.

AU - Spencer, R.

AU - Arnwine, J.

AU - Berry, P. M.

AU - Leffler, J. N.

AU - Stager, D. R.

PY - 2001

Y1 - 2001

N2 - Objective: To evaluate outcomes at 10 years after randomization for eyes undergoing cryotherapy vs eyes serving as controls, for patients enrolled in the Multicenter Trial of Cryotherapy for Retinopathy of Prematurity (CRYO-ROP). Methods: The randomized cohort originally consisted of 291 preterm children with birth weights less than 1251 g who developed a defined threshold of ROP severity in one or both eyes. Patients with bilateral threshold ROP (n = 240) were randomly assigned to receive cryotherapy to one eye and no cryotherapy to the other eye. Those with ROP of less severity than threshold in the fellow eye ("asymmetric"; n = 51) were randomly assigned to cryotherapy or no cryotherapy in the eye with threshold ROP. Ten years later, a tester who was masked to treatment status of each eye measured distance and near visual acuity, with "unfavorable" outcome being 20/200 or worse. Patients also were evaluated by study-certified ophthalmologists who assessed ROP residua primarily in the posterior pole of the fundus, with unfavorable outcome being a posterior retinal fold or worse. Results: For the 247 children examined, both functional and structural primary outcomes showed fewer unfavorable outcomes in treated vs control eyes: 44.4% vs 62.1% (P

AB - Objective: To evaluate outcomes at 10 years after randomization for eyes undergoing cryotherapy vs eyes serving as controls, for patients enrolled in the Multicenter Trial of Cryotherapy for Retinopathy of Prematurity (CRYO-ROP). Methods: The randomized cohort originally consisted of 291 preterm children with birth weights less than 1251 g who developed a defined threshold of ROP severity in one or both eyes. Patients with bilateral threshold ROP (n = 240) were randomly assigned to receive cryotherapy to one eye and no cryotherapy to the other eye. Those with ROP of less severity than threshold in the fellow eye ("asymmetric"; n = 51) were randomly assigned to cryotherapy or no cryotherapy in the eye with threshold ROP. Ten years later, a tester who was masked to treatment status of each eye measured distance and near visual acuity, with "unfavorable" outcome being 20/200 or worse. Patients also were evaluated by study-certified ophthalmologists who assessed ROP residua primarily in the posterior pole of the fundus, with unfavorable outcome being a posterior retinal fold or worse. Results: For the 247 children examined, both functional and structural primary outcomes showed fewer unfavorable outcomes in treated vs control eyes: 44.4% vs 62.1% (P

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JO - JAMA Ophthalmology

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