TY - JOUR
T1 - Multicenter linkage study of schizophrenia candidate regions on chromosomes 5q, 6q, 10p, and 13q
T2 - Schizophrenia linkage collaborative group III
AU - Levinson, Douglas F.
AU - Holmans, Peter
AU - Straub, Richard E.
AU - Owen, Michael J.
AU - Wildenauer, Dieter B.
AU - Gejman, Pablo V.
AU - Pulver, Ann E.
AU - Laurent, Claudine
AU - Kendler, Kenneth S.
AU - Walsh, Dermot
AU - Norton, N.
AU - Williams, Nigel M.
AU - Schwab, Sibylle G.
AU - Lerer, Bernard
AU - Mowry, Bryan J.
AU - Sanders, Alan R.
AU - Antonarakis, Stylianos E.
AU - Blouin, Jean Louis
AU - DeLeuze, Jean Francois
AU - Mallet, Jacques
N1 - Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2000
Y1 - 2000
N2 - Schizophrenia candidate regions 33-51 cM in length on chromosomes 5q, 6q, 10p, and 13q were investigated for genetic linkage with mapped markers with an average spacing of 5.64 cM. We studied 734 informative multiplex pedigrees (824 independent affected sibling pairs [ASPs], or 1, 003 ASPs when all possible pairs are counted), which were collected in eight centers. Cases with diagnoses of schizophrenia or schizoaffective disorder (DSM-IIIR criteria) were considered affected (n = 1, 937). Data were analyzed with multipoint methods, including nonparametric linkage (NPL), ASP analysis using the possible-triangle method, and logistic-regression analysis of identity-by-descent (IBD) sharing in ASPs with sample as a covariate, in a test for intersample heterogeneity and for linkage with allowance for intersample heterogeneity. The data most supportive for linkage to schizophrenia were from chromosome 6q; logistic-regression analysis of linkage allowing for intersample heterogeneity produced an empirical P value < .0002 with, or P = .0004 without, inclusion of the sample that produced the first positive report in this region; the maximum NPL score in this region was 2.47 (P = .0046), the maximum LOD score (MLS) from ASP analysis was 3.10 (empirical P = .0036), and there was significant evidence for intersample heterogeneity (empirical P = .0038). More-modest support for linkage was observed for chromosome 10p, with logistic-regression analysis of linkage producing an empirical P = .045 and with significant evidence for intersample heterogeneity (empirical P = .0096).
AB - Schizophrenia candidate regions 33-51 cM in length on chromosomes 5q, 6q, 10p, and 13q were investigated for genetic linkage with mapped markers with an average spacing of 5.64 cM. We studied 734 informative multiplex pedigrees (824 independent affected sibling pairs [ASPs], or 1, 003 ASPs when all possible pairs are counted), which were collected in eight centers. Cases with diagnoses of schizophrenia or schizoaffective disorder (DSM-IIIR criteria) were considered affected (n = 1, 937). Data were analyzed with multipoint methods, including nonparametric linkage (NPL), ASP analysis using the possible-triangle method, and logistic-regression analysis of identity-by-descent (IBD) sharing in ASPs with sample as a covariate, in a test for intersample heterogeneity and for linkage with allowance for intersample heterogeneity. The data most supportive for linkage to schizophrenia were from chromosome 6q; logistic-regression analysis of linkage allowing for intersample heterogeneity produced an empirical P value < .0002 with, or P = .0004 without, inclusion of the sample that produced the first positive report in this region; the maximum NPL score in this region was 2.47 (P = .0046), the maximum LOD score (MLS) from ASP analysis was 3.10 (empirical P = .0036), and there was significant evidence for intersample heterogeneity (empirical P = .0038). More-modest support for linkage was observed for chromosome 10p, with logistic-regression analysis of linkage producing an empirical P = .045 and with significant evidence for intersample heterogeneity (empirical P = .0096).
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U2 - 10.1086/303041
DO - 10.1086/303041
M3 - Article
C2 - 10924404
AN - SCOPUS:0033842462
VL - 67
SP - 652
EP - 663
JO - American Journal of Human Genetics
JF - American Journal of Human Genetics
SN - 0002-9297
IS - 3
ER -