Multicenter analytical performance evaluation of the Elecsys® proBNP assay

Lori J Sokoll, Hannsjörg Baum, Paul O. Collinson, Eberhard Gurr, Markus Haass, Hilmar Luthe, James J. Morton, William Nowatzke, Christiana Zingler

Research output: Contribution to journalArticle

Abstract

The purpose of this multicenter study was to evaluate the technical performance of the automated Elecsys proBNP (brain natriuretic peptide) assay, which is indicated as an aid in the diagnosis of individuals suspeded of having congestive heart faillure. The Elecsys proBNP assay is an electrochemiluminescent immunoassay employing two polyclonal NT-proBNP-specific antibodies in a sandwich test format. The study was performed on the three Elecsys analyzers (E 1010, E 2010, and E 170) at eight different sites world-wide. Within- and total precision were ≤3%, with total precision slightly higher on the Elecsys E 170 instrument with multiple modules. Reproducibility among sites and platforms was

Original languageEnglish (US)
Pages (from-to)965-972
Number of pages8
JournalClinical Chemistry and Laboratory Medicine
Volume42
Issue number8
DOIs
StatePublished - 2004

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Brain Natriuretic Peptide
Immunoassay
Multicenter Studies
Assays
Antibodies
pro-brain natriuretic peptide (1-76)

Keywords

  • Analytical performance
  • Brain natriuretic peptide (BNP)
  • Congestive heart failure
  • NT-proBNP
  • proBNP

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Multicenter analytical performance evaluation of the Elecsys® proBNP assay. / Sokoll, Lori J; Baum, Hannsjörg; Collinson, Paul O.; Gurr, Eberhard; Haass, Markus; Luthe, Hilmar; Morton, James J.; Nowatzke, William; Zingler, Christiana.

In: Clinical Chemistry and Laboratory Medicine, Vol. 42, No. 8, 2004, p. 965-972.

Research output: Contribution to journalArticle

Sokoll, LJ, Baum, H, Collinson, PO, Gurr, E, Haass, M, Luthe, H, Morton, JJ, Nowatzke, W & Zingler, C 2004, 'Multicenter analytical performance evaluation of the Elecsys® proBNP assay', Clinical Chemistry and Laboratory Medicine, vol. 42, no. 8, pp. 965-972. https://doi.org/10.1515/CCLM.2004.157
Sokoll, Lori J ; Baum, Hannsjörg ; Collinson, Paul O. ; Gurr, Eberhard ; Haass, Markus ; Luthe, Hilmar ; Morton, James J. ; Nowatzke, William ; Zingler, Christiana. / Multicenter analytical performance evaluation of the Elecsys® proBNP assay. In: Clinical Chemistry and Laboratory Medicine. 2004 ; Vol. 42, No. 8. pp. 965-972.
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