Multicenter analysis of stenting in symptomatic intracranial atherosclerosis

Wei Jian Jiang, Esteban Cheng-Ching, Alex Abou-Chebl, Osama O. Zaidat, Tudor G. Jovin, Junaid Kalia, Muhammad Shazam Hussain, Ridwan Lin, Amer M. Malik, Ferdinand Hui, Rishi Gupta

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


BACKGROUND: Stenting for symptomatic intracranial atherosclerotic disease is a therapeutic option in patients in whom medical therapy fails. OBJECTIVE: To determine the periprocedural complication rates and mid-term restenosis rates in patients treated with balloon-expandable stents (BESs) compared with selfexpanding stents (SESs). METHODS: A retrospective review of consecutive patients treated with intracranial stents at 5 institutions was performed. Predictors of 30-day stroke and death as well as mid-term restenosis rates were analyzed. RESULTS: A total of 670 lesions were treated in 637 patients with a mean age of 57 ± 13 years. A total of 454 lesions (68%) were treated with BESs and 216 lesions (32%) with SESs. The overall 30-day periprocedural complication rate was 6.1%, without any difference noted between the 2 groups. Patients treated within 24 hours of the index event were significantly more likely to have experienced a periprocedural complication (odds ratio [OR], 4.0; 95% confidence interval [CI]: 1.7-6.7; P, <007), whereas focal lesions were less likely to have a complication (OR, 0.31; 95% CI: 0.13-0.72; P, <001). Midterm restenosis was less likely in patients with a lower percentage of posttreatment stenosis (OR, 0.97; 95% CI: 0.95-0.99; P, <006), which was more common in BES-treated patients and focal concentric lesions (OR, 0.33; 95% CI: 0.23-0.55; P, <0001). CONCLUSION: BESs have periprocedural complication rates similar to those of SESs. Less posttreatment stenosis was associated with lower rates of mid-term restenosis. Future randomized trials comparing BESs and SESs may help to identify the stent type that is safest and most durable.

Original languageEnglish (US)
Pages (from-to)25-30
Number of pages6
Issue number1
StatePublished - Jan 1 2012
Externally publishedYes


  • Angioplasty
  • Intracranial stenosis
  • Intracranial stenting
  • Ischemic stroke
  • Stent

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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