TY - JOUR
T1 - Multicenter analysis of stenting in symptomatic intracranial atherosclerosis
AU - Jiang, Wei Jian
AU - Cheng-Ching, Esteban
AU - Abou-Chebl, Alex
AU - Zaidat, Osama O.
AU - Jovin, Tudor G.
AU - Kalia, Junaid
AU - Hussain, Muhammad Shazam
AU - Lin, Ridwan
AU - Malik, Amer M.
AU - Hui, Ferdinand
AU - Gupta, Rishi
PY - 2012/1/1
Y1 - 2012/1/1
N2 - BACKGROUND: Stenting for symptomatic intracranial atherosclerotic disease is a therapeutic option in patients in whom medical therapy fails. OBJECTIVE: To determine the periprocedural complication rates and mid-term restenosis rates in patients treated with balloon-expandable stents (BESs) compared with selfexpanding stents (SESs). METHODS: A retrospective review of consecutive patients treated with intracranial stents at 5 institutions was performed. Predictors of 30-day stroke and death as well as mid-term restenosis rates were analyzed. RESULTS: A total of 670 lesions were treated in 637 patients with a mean age of 57 ± 13 years. A total of 454 lesions (68%) were treated with BESs and 216 lesions (32%) with SESs. The overall 30-day periprocedural complication rate was 6.1%, without any difference noted between the 2 groups. Patients treated within 24 hours of the index event were significantly more likely to have experienced a periprocedural complication (odds ratio [OR], 4.0; 95% confidence interval [CI]: 1.7-6.7; P, <007), whereas focal lesions were less likely to have a complication (OR, 0.31; 95% CI: 0.13-0.72; P, <001). Midterm restenosis was less likely in patients with a lower percentage of posttreatment stenosis (OR, 0.97; 95% CI: 0.95-0.99; P, <006), which was more common in BES-treated patients and focal concentric lesions (OR, 0.33; 95% CI: 0.23-0.55; P, <0001). CONCLUSION: BESs have periprocedural complication rates similar to those of SESs. Less posttreatment stenosis was associated with lower rates of mid-term restenosis. Future randomized trials comparing BESs and SESs may help to identify the stent type that is safest and most durable.
AB - BACKGROUND: Stenting for symptomatic intracranial atherosclerotic disease is a therapeutic option in patients in whom medical therapy fails. OBJECTIVE: To determine the periprocedural complication rates and mid-term restenosis rates in patients treated with balloon-expandable stents (BESs) compared with selfexpanding stents (SESs). METHODS: A retrospective review of consecutive patients treated with intracranial stents at 5 institutions was performed. Predictors of 30-day stroke and death as well as mid-term restenosis rates were analyzed. RESULTS: A total of 670 lesions were treated in 637 patients with a mean age of 57 ± 13 years. A total of 454 lesions (68%) were treated with BESs and 216 lesions (32%) with SESs. The overall 30-day periprocedural complication rate was 6.1%, without any difference noted between the 2 groups. Patients treated within 24 hours of the index event were significantly more likely to have experienced a periprocedural complication (odds ratio [OR], 4.0; 95% confidence interval [CI]: 1.7-6.7; P, <007), whereas focal lesions were less likely to have a complication (OR, 0.31; 95% CI: 0.13-0.72; P, <001). Midterm restenosis was less likely in patients with a lower percentage of posttreatment stenosis (OR, 0.97; 95% CI: 0.95-0.99; P, <006), which was more common in BES-treated patients and focal concentric lesions (OR, 0.33; 95% CI: 0.23-0.55; P, <0001). CONCLUSION: BESs have periprocedural complication rates similar to those of SESs. Less posttreatment stenosis was associated with lower rates of mid-term restenosis. Future randomized trials comparing BESs and SESs may help to identify the stent type that is safest and most durable.
KW - Angioplasty
KW - Intracranial stenosis
KW - Intracranial stenting
KW - Ischemic stroke
KW - Stent
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U2 - 10.1227/NEU.0b013e31822d274d
DO - 10.1227/NEU.0b013e31822d274d
M3 - Article
C2 - 21795866
AN - SCOPUS:84856119003
SN - 0148-396X
VL - 70
SP - 25
EP - 30
JO - Neurosurgery
JF - Neurosurgery
IS - 1
ER -