Multicenter AIDS Cohort Study Quantitative Coronary Plaque Progression Study: Rationale and design

Rine Nakanishi, Wendy S Post, Kazuhiro Osawa, Eranthi Jayawardena, Michael Kim, Nasim Sheidaee, Negin Nezarat, Sina Rahmani, Nicholas Kim, Nicolai Hathiramani, Shriraj Susarla, Frank Palella, Mallory Witt, Michael Blaha, Todd T Brown, Lawrence Kingsley, Sabina Haberlen, Christopher Dailing, Matthew J. Budoff

Research output: Contribution to journalArticle

Abstract

Background and aim The association of HIV with coronary atherosclerosis has been established; however, the progression of coronary atherosclerosis over time among participants with HIV is not well known. The Multicenter AIDS Cohort Study Quantitative Coronary Plaque Progression Study is a large prospective multicenter study quantifying progression of coronary plaque assessed by serial coronary computed tomography angiography (CTA). Patients and methods HIV-infected and uninfected men who were enrolled in the Multicenter AIDS Cohort Study Cardiovascular Substudy were eligible to complete a follow-up contrast coronary CTA 3-6 years after baseline. We measured coronary plaque volume and characteristics (calcified and noncalcified plaque including fibrous, fibrous-fatty, and low attenuation) and vulnerable plaque among HIV-infected and uninfected men using semiautomated plaque software to investigate the progression of coronary atherosclerosis over time. Conclusion We describe a novel, large prospective multicenter study investigating incidence, transition of characteristics, and progression in coronary atherosclerosis quantitatively assessed by serial coronary CTAs among HIV-infected and uninfected men.

Original languageEnglish (US)
Pages (from-to)23-29
Number of pages7
JournalCoronary Artery Disease
Volume29
Issue number1
DOIs
StatePublished - Jan 1 2018

Keywords

  • coronary artery disease
  • coronary computed tomographic angiography
  • HIV
  • plaque progression
  • vulnerable plaque

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Nakanishi, R., Post, W. S., Osawa, K., Jayawardena, E., Kim, M., Sheidaee, N., Nezarat, N., Rahmani, S., Kim, N., Hathiramani, N., Susarla, S., Palella, F., Witt, M., Blaha, M., Brown, T. T., Kingsley, L., Haberlen, S., Dailing, C., & Budoff, M. J. (2018). Multicenter AIDS Cohort Study Quantitative Coronary Plaque Progression Study: Rationale and design. Coronary Artery Disease, 29(1), 23-29. https://doi.org/10.1097/MCA.0000000000000546