Multi-vendor standardized sequence for edited magnetic resonance spectroscopy

Muhammad G. Saleh, Daniel Rimbault, Mark Mikkelsen, Georg Oeltzschner, Anna M. Wang, Dengrong Jiang, Ali Alhamud, Jamie Near, Michael Schar, Ralph Noeske, James B. Murdoch, Lars Ersland, Alexander R. Craven, Gerard Eric Dwyer, Eli Renate Grüner, Li Pan, Sinyeob Ahn, Richard Anthony Edward Edden

Research output: Contribution to journalArticle

Abstract

Spectral editing allows direct measurement of low-concentration metabolites, such as GABA, glutathione (GSH) and lactate (Lac), relevant for understanding brain (patho)physiology. The most widely used spectral editing technique is MEGA-PRESS, which has been diversely implemented across research sites and vendors, resulting in variations in the final resolved edited signal. In this paper, we describe an effort to develop a new universal MEGA-PRESS sequence with HERMES functionality for the major MR vendor platforms with standardized RF pulse shapes, durations, amplitudes and timings. New RF pulses were generated for the universal sequence. Phantom experiments were conducted on Philips, Siemens, GE and Canon 3 T MRI scanners using 32-channel head coils. In vivo experiments were performed on the same six subjects on Philips and Siemens scanners, and on two additional subjects, one on GE and one on Canon scanners. On each platform, edited MRS experiments were conducted with the vendor-native and universal MEGA-PRESS sequences for GABA (TE = 68 ms) and Lac editing (TE = 140 ms). Additionally, HERMES for GABA and GSH was performed using the universal sequence at TE = 80 ms. The universal sequence improves inter-vendor similarity of GABA-edited and Lac-edited MEGA-PRESS spectra. The universal HERMES sequence yields both GABA- and GSH-edited spectra with negligible levels of crosstalk on all four platforms, and with strong agreement among vendors for both edited spectra. In vivo GABA+/Cr, Lac/Cr and GSH/Cr ratios showed relatively low variation between scanners using the universal sequence. In conclusion, phantom and in vivo experiments demonstrate successful implementation of the universal sequence across all four major vendors, allowing editing of several metabolites across a range of TEs.

Original languageEnglish (US)
Pages (from-to)425-431
Number of pages7
JournalNeuroImage
Volume189
DOIs
StatePublished - Apr 1 2019

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gamma-Aminobutyric Acid
Magnetic Resonance Spectroscopy
Lactic Acid
Glutathione
Head
Brain
Research

Keywords

  • Edited MRS
  • HERMES
  • Magnetic resonance spectroscopy
  • MEGA-PRESS
  • Standardization

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

Cite this

Saleh, M. G., Rimbault, D., Mikkelsen, M., Oeltzschner, G., Wang, A. M., Jiang, D., ... Edden, R. A. E. (2019). Multi-vendor standardized sequence for edited magnetic resonance spectroscopy. NeuroImage, 189, 425-431. https://doi.org/10.1016/j.neuroimage.2019.01.056

Multi-vendor standardized sequence for edited magnetic resonance spectroscopy. / Saleh, Muhammad G.; Rimbault, Daniel; Mikkelsen, Mark; Oeltzschner, Georg; Wang, Anna M.; Jiang, Dengrong; Alhamud, Ali; Near, Jamie; Schar, Michael; Noeske, Ralph; Murdoch, James B.; Ersland, Lars; Craven, Alexander R.; Dwyer, Gerard Eric; Grüner, Eli Renate; Pan, Li; Ahn, Sinyeob; Edden, Richard Anthony Edward.

In: NeuroImage, Vol. 189, 01.04.2019, p. 425-431.

Research output: Contribution to journalArticle

Saleh, MG, Rimbault, D, Mikkelsen, M, Oeltzschner, G, Wang, AM, Jiang, D, Alhamud, A, Near, J, Schar, M, Noeske, R, Murdoch, JB, Ersland, L, Craven, AR, Dwyer, GE, Grüner, ER, Pan, L, Ahn, S & Edden, RAE 2019, 'Multi-vendor standardized sequence for edited magnetic resonance spectroscopy', NeuroImage, vol. 189, pp. 425-431. https://doi.org/10.1016/j.neuroimage.2019.01.056
Saleh MG, Rimbault D, Mikkelsen M, Oeltzschner G, Wang AM, Jiang D et al. Multi-vendor standardized sequence for edited magnetic resonance spectroscopy. NeuroImage. 2019 Apr 1;189:425-431. https://doi.org/10.1016/j.neuroimage.2019.01.056
Saleh, Muhammad G. ; Rimbault, Daniel ; Mikkelsen, Mark ; Oeltzschner, Georg ; Wang, Anna M. ; Jiang, Dengrong ; Alhamud, Ali ; Near, Jamie ; Schar, Michael ; Noeske, Ralph ; Murdoch, James B. ; Ersland, Lars ; Craven, Alexander R. ; Dwyer, Gerard Eric ; Grüner, Eli Renate ; Pan, Li ; Ahn, Sinyeob ; Edden, Richard Anthony Edward. / Multi-vendor standardized sequence for edited magnetic resonance spectroscopy. In: NeuroImage. 2019 ; Vol. 189. pp. 425-431.
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