Multi-scale models of local control of calcium induced calcium release

R. Hinch, J. L. Greenstein, R. L. Winslow

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Calcium-induced-calcium-release in cardiac myocytes is the release of Ca2+ from the sarcoplasmic reticulum (SR) triggered by Ca 2+ entering the cell through L-type Ca2+ channels. The Ca2+ is released through ryanodine receptors which 'sense' local [Ca2+] in the small region (the diadic space) positioned between the t-tubules and the SR. The length-scale of a single diad is of the order of 10 nm and the diffusion time-scale is of order of 1μs with each cell containing approximately 10,000 diadic spaces which act independently. However, typically one is interested in Ca2+ currents at the whole cell level and higher. This is a multi-scale problem and cannot be solved by direct computation. In this paper we develop a general framework for deriving approximate solutions of these models.

Original languageEnglish (US)
Pages (from-to)136-150
Number of pages15
JournalProgress in Biophysics and Molecular Biology
Issue number1-3
StatePublished - Jan 2006


  • CICR
  • Calcium-induced-calcium-release
  • Excitation-contraction coupling
  • Local control theory
  • Multi-scale modelling

ASJC Scopus subject areas

  • Biophysics
  • Molecular Biology


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