Multi-scale modeling of gene regulatory networks via integration of temporal and topological biological data

George Dimitrakopoulos, Kyriakos Sgarbas, Konstantina Dimitrakopoulou, Andrei Dragomir, Anastasios Bezerianos, Ioannis A. Maraziotis

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Regulome is the dynamic network representation of the regulatory interplay among genes, proteins and other cellular components that control cellular processes. Reconstruction of gene regulatory networks (GRN) delineates one of the main objectives of Systems Biology towards understanding the organization of regulome. Significant progress has been reported the last years regarding GRN reconstruction methods, but the majority of them either consider information originating solely from gene expression data or/and are applied on a small fraction of the experimental dataset. In this paper, we will describe an integrative method, utilizing both temporal information arriving from time-series gene expression profiles, as well as topological properties of protein networks. The proposed methodology detects relations among either groups of genes or specific genes depending on the level of abstraction or resolution requested. Application on real data proved the ability of the method to extract relations in accordance with current biological knowledge as well as discriminate between different experimental conditions.

Original languageEnglish (US)
Title of host publication2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2012
Pages1242-1245
Number of pages4
DOIs
StatePublished - Dec 14 2012
Event34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012 - San Diego, CA, United States
Duration: Aug 28 2012Sep 1 2012

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)1557-170X

Other

Other34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012
CountryUnited States
CitySan Diego, CA
Period8/28/129/1/12

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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