Multi-scale Coarse-to-Fine Segmentation for Screening Pancreatic Ductal Adenocarcinoma

Zhuotun Zhu, Yingda Xia, Lingxi Xie, Elliot K. Fishman, Alan L. Yuille

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We propose an intuitive approach of detecting pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer, by checking abdominal CT scans. Our idea is named multi-scale segmentation-for-classification, which classifies volumes by checking if at least a sufficient number of voxels is segmented as tumors, by which we can provide radiologists with tumor locations. In order to deal with tumors with different scales, we train and test our volumetric segmentation networks with multi-scale inputs in a coarse-to-fine flowchart. A post-processing module is used to filter out outliers and reduce false alarms. We collect a new dataset containing 439 CT scans, in which 136 cases were diagnosed with PDAC and 303 cases are normal, which is the largest set for PDAC tumors to the best of our knowledge. To offer the best trade-off between sensitivity and specificity, our proposed framework reports a sensitivity of 94.1 % at a specificity of 98.5 %, which demonstrates the potential to make a clinical impact.

Original languageEnglish (US)
Title of host publicationMedical Image Computing and Computer Assisted Intervention – MICCAI 2019 - 22nd International Conference, Proceedings
EditorsDinggang Shen, Pew-Thian Yap, Tianming Liu, Terry M. Peters, Ali Khan, Lawrence H. Staib, Caroline Essert, Sean Zhou
PublisherSpringer
Pages3-12
Number of pages10
ISBN (Print)9783030322250
DOIs
StatePublished - Jan 1 2019
Event22nd International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2019 - Shenzhen, China
Duration: Oct 13 2019Oct 17 2019

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume11769 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference22nd International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2019
CountryChina
CityShenzhen
Period10/13/1910/17/19

Keywords

  • CT scan
  • Pancreas segmentation
  • PDAC

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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  • Cite this

    Zhu, Z., Xia, Y., Xie, L., Fishman, E. K., & Yuille, A. L. (2019). Multi-scale Coarse-to-Fine Segmentation for Screening Pancreatic Ductal Adenocarcinoma. In D. Shen, P-T. Yap, T. Liu, T. M. Peters, A. Khan, L. H. Staib, C. Essert, & S. Zhou (Eds.), Medical Image Computing and Computer Assisted Intervention – MICCAI 2019 - 22nd International Conference, Proceedings (pp. 3-12). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 11769 LNCS). Springer. https://doi.org/10.1007/978-3-030-32226-7_1