Multi-scale cellular engineering: From molecules to organ-on-a-chip

Ngan F. Huang; Ovijit Chaudhuri; Patrick Cahan; Aijun Wang; Adam J. Engler; Yingxiao Wang; Sanjay Kumar; Ali Khademhosseini; Song Li

doi:10.1063/1.5129788

Multi-scale cellular engineering: From molecules to organ-on-a-chip

Ngan F. Huang, Ovijit Chaudhuri, Patrick Cahan, Aijun Wang, Adam J. Engler, Yingxiao Wang, Sanjay Kumar, Ali Khademhosseini, Song Li

School of Medicine

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

Recent technological advances in cellular and molecular engineering have provided new insights into biology and enabled the design, manufacturing, and manipulation of complex living systems. Here, we summarize the state of advances at the molecular, cellular, and multi-cellular levels using experimental and computational tools. The areas of focus include intrinsically disordered proteins, synthetic proteins, spatiotemporally dynamic extracellular matrices, organ-on-a-chip approaches, and computational modeling, which all have tremendous potential for advancing fundamental and translational science. Perspectives on the current limitations and future directions are also described, with the goal of stimulating interest to overcome these hurdles using multi-disciplinary approaches.

Original language	English (US)
Article number	010906
Journal	APL Bioengineering
Volume	4
Issue number	1
DOIs	https://doi.org/10.1063/1.5129788
State	Published - Mar 1 2020

ASJC Scopus subject areas

Bioengineering
Biophysics
Biomedical Engineering
Biomaterials

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abstract = "Recent technological advances in cellular and molecular engineering have provided new insights into biology and enabled the design, manufacturing, and manipulation of complex living systems. Here, we summarize the state of advances at the molecular, cellular, and multi-cellular levels using experimental and computational tools. The areas of focus include intrinsically disordered proteins, synthetic proteins, spatiotemporally dynamic extracellular matrices, organ-on-a-chip approaches, and computational modeling, which all have tremendous potential for advancing fundamental and translational science. Perspectives on the current limitations and future directions are also described, with the goal of stimulating interest to overcome these hurdles using multi-disciplinary approaches.",

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AU - Huang, Ngan F.

AU - Chaudhuri, Ovijit

AU - Cahan, Patrick

AU - Wang, Aijun

AU - Engler, Adam J.

AU - Wang, Yingxiao

AU - Kumar, Sanjay

AU - Khademhosseini, Ali

AU - Li, Song

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AB - Recent technological advances in cellular and molecular engineering have provided new insights into biology and enabled the design, manufacturing, and manipulation of complex living systems. Here, we summarize the state of advances at the molecular, cellular, and multi-cellular levels using experimental and computational tools. The areas of focus include intrinsically disordered proteins, synthetic proteins, spatiotemporally dynamic extracellular matrices, organ-on-a-chip approaches, and computational modeling, which all have tremendous potential for advancing fundamental and translational science. Perspectives on the current limitations and future directions are also described, with the goal of stimulating interest to overcome these hurdles using multi-disciplinary approaches.

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Multi-scale cellular engineering: From molecules to organ-on-a-chip

Abstract

ASJC Scopus subject areas

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