Multi-pulse drug delivery from a resorbable polymeric microchip device

Amy C. Richards Grayson; Insung S. Choi; Betty M. Tyler; Paul P. Wang; Henry Brem; Michael J. Cima; Robert Langer

doi:10.1038/nmat998

Multi-pulse drug delivery from a resorbable polymeric microchip device

Amy C. Richards Grayson, Insung S. Choi, Betty M. Tyler, Paul P. Wang, Henry Brem, Michael J. Cima, Robert Langer

School of Medicine

Research output: Contribution to journal › Article › peer-review

339 Scopus citations

Abstract

Controlled-release drug delivery systems have many applications including treatments for hormone deficiencies and chronic pain. A biodegradable device that could provide multi-dose drug delivery would be advantageous for long-term treatment of conditions requiring pulsatile drug release. In this work, biodegradable polymeric microchips were fabricated that released four pulses of radiolabelled dextran, human growth hormone or heparin in vitro. Heparin that was released over 142 days retained on average 96 ± 12% of its bioactivity. The microchips were 1.2 cm in diameter, 480-560 μm thick and had 36 reservoirs that could each be filled with a different chemical. The devices were fabricated from poly(L-lactic acid) and had poly(D,L-lactic-co-glycolic acid) membranes of different molecular masses covering the reservoirs. A drug delivery system can be designed with the potential to release pulses of different drugs at intervals after implantation in a patient by using different molecular masses or materials for the membrane.

Original language	English (US)
Pages (from-to)	767-772
Number of pages	6
Journal	Nature Materials
Volume	2
Issue number	11
DOIs	https://doi.org/10.1038/nmat998
State	Published - Nov 2003

ASJC Scopus subject areas

General Chemistry
General Materials Science
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

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title = "Multi-pulse drug delivery from a resorbable polymeric microchip device",

abstract = "Controlled-release drug delivery systems have many applications including treatments for hormone deficiencies and chronic pain. A biodegradable device that could provide multi-dose drug delivery would be advantageous for long-term treatment of conditions requiring pulsatile drug release. In this work, biodegradable polymeric microchips were fabricated that released four pulses of radiolabelled dextran, human growth hormone or heparin in vitro. Heparin that was released over 142 days retained on average 96 ± 12% of its bioactivity. The microchips were 1.2 cm in diameter, 480-560 μm thick and had 36 reservoirs that could each be filled with a different chemical. The devices were fabricated from poly(L-lactic acid) and had poly(D,L-lactic-co-glycolic acid) membranes of different molecular masses covering the reservoirs. A drug delivery system can be designed with the potential to release pulses of different drugs at intervals after implantation in a patient by using different molecular masses or materials for the membrane.",

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note = "Funding Information: This work was supported by the National Institutes of Health Bioengineering Research Partnership grant R24-AI47739-02.A.C.R.G. thanks the American Association of University Women and the National Science Foundation for fellowship funding. I.S.C. thanks the Korea Science and Engineering Foundation and the Brain Korea 21 project. Correspondence and requests for materials should be addressed to R.L. Supplementary Information accompanies the paper on www.nature.com/naturematerials",

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AU - Cima, Michael J.

AU - Langer, Robert

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Multi-pulse drug delivery from a resorbable polymeric microchip device

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