Multi-Omics Resolves a Sharp Disease-State Shift between Mild and Moderate COVID-19

the ISB-Swedish COVID19 Biobanking Unit

Research output: Contribution to journalArticlepeer-review

Abstract

Using serial blood draws from COVID-19 patients, Su et al. present an extensive multi-omics dataset of plasma and single PBMCs covering the first week of infection following clinical diagnosis, which includes information on plasma proteins, metabolites, and on PBMC transcriptomic and surface-protein data, immune receptor sequences, secreted proteins, and electronic health record data. Their integrated analysis identifies a major immunological shift between mild and moderate infection, which includes an increase in inflammation, drop in blood nutrients, and the emergence of novel immune cell subpopulations that intensify with disease severity.

Original languageEnglish (US)
Pages (from-to)1479-1495.e20
JournalCell
Volume183
Issue number6
DOIs
StatePublished - Dec 10 2020
Externally publishedYes

Keywords

  • CITE-seq
  • COVID-19
  • immune response
  • infection
  • metabolomics
  • multi-omics
  • proteomics
  • single-cell RNA-seq
  • single-cell TCR-seq
  • single-cell secretome

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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