Multi-modal validation framework of mitral valve geometry and functional computational models

Sasa Grbic, Thomas F. Easley, Tommaso Mansi, Charles H. Bloodworth, Eric L. Pierce, Ingmar Voigt, Dominik Neumann, Julian Krebs, David D. Yuh, Morten O. Jensen, Dorin Comaniciu, Ajit P. Yoganathan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

Computational models of the mitral valve (MV) exhibit significant potential for patient-specific surgical planning. Recently, these models have been advanced by incorporating MV tissue structure, nonlinear material properties, and more realistic chordae tendineae architecture. Despite advances, only limited ground-truth data exists to validate their ability to accurately simulate MV closure and function. The validation of the underlying models will enhance modeling accuracy and confidence in the simulated results. A necessity towards this aim is to develop an integrated pipeline based on a comprehensive in-vitro flow loop setup including echocardiography techniques (Echo) and microcomputed tomography. Building on [1] we improved the acquisition protocol of the proposed experimental setup for in-vitro Echo imaging, which enables the extraction of more reproducible and accurate geometrical models, using state-of-the art image processing and geometric modeling techniques. Based on the geometrical parameters from the Echo MV models captured during diastole, a bio-mechanical model is derived to estimate MV closure geometry. We illustrate the framework on two data sets and show the improvements obtained from the novel Echo acquisition protocol and improved bio-mechanical model.

Original languageEnglish (US)
Title of host publicationStatistical Atlases and Computational Models of the Heart
Subtitle of host publicationImaging and Modelling Challenges - 5th International Workshop, STACOM 2014 Held in Conjunction with MICCAI 2014, Revised Selected Papers
EditorsMihaela Pop, Tommaso Mansi, Oscar Camara, Maxime Sermesant, Alistair Young, Kawal Rhode, Kawal Rhode
PublisherSpringer Verlag
Pages239-248
Number of pages10
ISBN (Electronic)9783319146775
DOIs
StatePublished - Jan 1 2015
Event5th International Workshop on Statistical Atlases and Computational Models of the Heart, STACOM 2014 Held in Conjunction with Medical Image Computing and Computer Assisted Intervention Conference, MICCAI 2014 - Boston, United States
Duration: Sep 18 2014Sep 18 2014

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume8896
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other5th International Workshop on Statistical Atlases and Computational Models of the Heart, STACOM 2014 Held in Conjunction with Medical Image Computing and Computer Assisted Intervention Conference, MICCAI 2014
Country/TerritoryUnited States
CityBoston
Period9/18/149/18/14

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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