Multi-Level Regulatory Interactions between NF-κB and the Pluripotency Factor Lin28

William T. Mills, Noor N. Nassar, Deepa Ravindra, Xinbei Li, Mollie K. Meffert

Research output: Contribution to journalReview articlepeer-review

Abstract

An appreciation for the complex interactions between the NF-κB transcription factor and the Lin28 RNA binding protein/let-7 microRNA pathways has grown substantially over the past decade. Both the NF-κB and Lin28/let-7 pathways are master regulators impacting cell survival, growth and proliferation, and an understanding of how interfaces between these pathways participate in governing pluripotency, progenitor differentiation, and neuroplastic responses remains an emerging area of research. In this review, we provide a concise summary of the respective pathways and focus on the function of signaling interactions at both the transcriptional and post-transcriptional levels. Regulatory loops capable of providing both reinforcing and extinguishing feedback have been described. We highlight convergent findings in disparate biological systems and indicate future directions for investigation.

Original languageEnglish (US)
JournalCells
Volume9
Issue number12
DOIs
StatePublished - Dec 17 2020

Keywords

  • Lin28
  • NF-κB
  • RNA-binding protein
  • let-7 microRNA
  • nervous system
  • neurodevelopment
  • pluripotency
  • transcription factor

ASJC Scopus subject areas

  • Medicine(all)

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