Multi-institutional Validation Study of the American Joint Commission on Cancer (8th Edition) Changes for T and N Staging in Patients with Pancreatic Adenocarcinoma

Peter J. Allen, Deborah Kuk, Carlos Fernandez del Castillo, Olca Basturk, Christopher Wolfgang, John L Cameron, Keith D. Lillemoe, Cristina R. Ferrone, Vicente Morales-Oyarvide, Jin He, Matthew J Weiss, Ralph H Hruban, Mithat Gönen, David S. Klimstra, Mari Mino-Kenudson

Research output: Contribution to journalArticle

Abstract

OBJECTIVE:: The aim of this study was to evaluate and validate the proposed 8th edition American Joint Committee on Cancer (AJCC) system for T and N staging of pancreatic adenocarcinoma. SUMMARY OF BACKGROUND DATA:: Investigators have questioned the clinical relevance and reproducibility of previous AJCC staging for pancreatic adenocarcinoma. METHODS:: Prospective databases at Memorial Sloan Kettering (MSK), Massachusetts General Hospital (MGH), and Johns Hopkins Hospital (JHH) were queried for patients who had undergone resection for pancreatic adenocarcinoma. Patients who underwent a margin-negative (R0) resection, and who had previously undergone pathologic review, were included. Patients were staged according to 7th edition AJCC criteria, as well as the proposed 8th edition system that includes different definitions of tumor size (T) and nodal status (N). The dataset was randomly split into training and test sets. RESULTS:: Two thousand three hundred eighteen patients were identified who met inclusion criteria. Recursive partitioning on the training set (n = 1551) identified statistically appropriate cutoffs for tumor size (

Original languageEnglish (US)
JournalAnnals of Surgery
DOIs
StateAccepted/In press - May 9 2016

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Validation Studies
Adenocarcinoma
Joints
Neoplasms
Neoplasm Staging
General Hospitals
Research Personnel
Databases

ASJC Scopus subject areas

  • Surgery

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Multi-institutional Validation Study of the American Joint Commission on Cancer (8th Edition) Changes for T and N Staging in Patients with Pancreatic Adenocarcinoma. / Allen, Peter J.; Kuk, Deborah; Castillo, Carlos Fernandez del; Basturk, Olca; Wolfgang, Christopher; Cameron, John L; Lillemoe, Keith D.; Ferrone, Cristina R.; Morales-Oyarvide, Vicente; He, Jin; Weiss, Matthew J; Hruban, Ralph H; Gönen, Mithat; Klimstra, David S.; Mino-Kenudson, Mari.

In: Annals of Surgery, 09.05.2016.

Research output: Contribution to journalArticle

Allen, Peter J. ; Kuk, Deborah ; Castillo, Carlos Fernandez del ; Basturk, Olca ; Wolfgang, Christopher ; Cameron, John L ; Lillemoe, Keith D. ; Ferrone, Cristina R. ; Morales-Oyarvide, Vicente ; He, Jin ; Weiss, Matthew J ; Hruban, Ralph H ; Gönen, Mithat ; Klimstra, David S. ; Mino-Kenudson, Mari. / Multi-institutional Validation Study of the American Joint Commission on Cancer (8th Edition) Changes for T and N Staging in Patients with Pancreatic Adenocarcinoma. In: Annals of Surgery. 2016.
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abstract = "OBJECTIVE:: The aim of this study was to evaluate and validate the proposed 8th edition American Joint Committee on Cancer (AJCC) system for T and N staging of pancreatic adenocarcinoma. SUMMARY OF BACKGROUND DATA:: Investigators have questioned the clinical relevance and reproducibility of previous AJCC staging for pancreatic adenocarcinoma. METHODS:: Prospective databases at Memorial Sloan Kettering (MSK), Massachusetts General Hospital (MGH), and Johns Hopkins Hospital (JHH) were queried for patients who had undergone resection for pancreatic adenocarcinoma. Patients who underwent a margin-negative (R0) resection, and who had previously undergone pathologic review, were included. Patients were staged according to 7th edition AJCC criteria, as well as the proposed 8th edition system that includes different definitions of tumor size (T) and nodal status (N). The dataset was randomly split into training and test sets. RESULTS:: Two thousand three hundred eighteen patients were identified who met inclusion criteria. Recursive partitioning on the training set (n = 1551) identified statistically appropriate cutoffs for tumor size (",
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AU - Basturk, Olca

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AU - Cameron, John L

AU - Lillemoe, Keith D.

AU - Ferrone, Cristina R.

AU - Morales-Oyarvide, Vicente

AU - He, Jin

AU - Weiss, Matthew J

AU - Hruban, Ralph H

AU - Gönen, Mithat

AU - Klimstra, David S.

AU - Mino-Kenudson, Mari

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