TY - GEN
T1 - Multi-function optogenetic stimulator and neural amplifier for wirelessly controlled neural interface
AU - Nag, Sudip
AU - Lee, Patrick
AU - Herikstad, Roger
AU - Sng, Judy
AU - Yen, Shih Cheng
AU - Thakor, Nitish V.
N1 - Funding Information:
National Research Foundation in Singapore for funding (NRF-CRP10-2012-01)
Publisher Copyright:
© 2015 IEEE.
PY - 2015/12/4
Y1 - 2015/12/4
N2 - The techniques of optogenetic stimulation and neural signal recording can be coupled together in order to realize a closed loop neural interface. An improved multifunction system has been presented that is able to generate single or multi-wavelength optical pulses as well as measure evoked neural potentials. The optical stimulator is based on blue (470 nm) and yellow (592 nm) LEDs. The neural recording amplifier consists of a low noise chip with an analog-To-digital converter (ADC), an impedance measurement hardware and a digital communication logic. In addition, wireless power and data transfer capabilities makes the system useful for a range of in-vivo studies. A safety feature against high temperature induced neural damage has also been incorporated. The entire system weighs approximately 4 gms and is packaged using an FDA-compliant biocompatible polymer for reliable and waterproof operation. In-vivo stimulation and recording experiments have been performed in the visual and motor cortices of transgenic CHR2 mice under anesthetized and partially awake conditions.
AB - The techniques of optogenetic stimulation and neural signal recording can be coupled together in order to realize a closed loop neural interface. An improved multifunction system has been presented that is able to generate single or multi-wavelength optical pulses as well as measure evoked neural potentials. The optical stimulator is based on blue (470 nm) and yellow (592 nm) LEDs. The neural recording amplifier consists of a low noise chip with an analog-To-digital converter (ADC), an impedance measurement hardware and a digital communication logic. In addition, wireless power and data transfer capabilities makes the system useful for a range of in-vivo studies. A safety feature against high temperature induced neural damage has also been incorporated. The entire system weighs approximately 4 gms and is packaged using an FDA-compliant biocompatible polymer for reliable and waterproof operation. In-vivo stimulation and recording experiments have been performed in the visual and motor cortices of transgenic CHR2 mice under anesthetized and partially awake conditions.
UR - http://www.scopus.com/inward/record.url?scp=84962635724&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84962635724&partnerID=8YFLogxK
U2 - 10.1109/BioCAS.2015.7348341
DO - 10.1109/BioCAS.2015.7348341
M3 - Conference contribution
AN - SCOPUS:84962635724
T3 - IEEE Biomedical Circuits and Systems Conference: Engineering for Healthy Minds and Able Bodies, BioCAS 2015 - Proceedings
BT - IEEE Biomedical Circuits and Systems Conference
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 11th IEEE Biomedical Circuits and Systems Conference, BioCAS 2015
Y2 - 22 October 2015 through 24 October 2015
ER -