Multi-function optogenetic stimulator and neural amplifier for wirelessly controlled neural interface

Sudip Nag, Patrick Lee, Roger Herikstad, Judy Sng, Shih Cheng Yen, Nitish V Thakor

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The techniques of optogenetic stimulation and neural signal recording can be coupled together in order to realize a closed loop neural interface. An improved multifunction system has been presented that is able to generate single or multi-wavelength optical pulses as well as measure evoked neural potentials. The optical stimulator is based on blue (470 nm) and yellow (592 nm) LEDs. The neural recording amplifier consists of a low noise chip with an analog-To-digital converter (ADC), an impedance measurement hardware and a digital communication logic. In addition, wireless power and data transfer capabilities makes the system useful for a range of in-vivo studies. A safety feature against high temperature induced neural damage has also been incorporated. The entire system weighs approximately 4 gms and is packaged using an FDA-compliant biocompatible polymer for reliable and waterproof operation. In-vivo stimulation and recording experiments have been performed in the visual and motor cortices of transgenic CHR2 mice under anesthetized and partially awake conditions.

Original languageEnglish (US)
Title of host publicationIEEE Biomedical Circuits and Systems Conference: Engineering for Healthy Minds and Able Bodies, BioCAS 2015 - Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Print)9781479972333
DOIs
StatePublished - Dec 4 2015
Event11th IEEE Biomedical Circuits and Systems Conference, BioCAS 2015 - Atlanta, United States
Duration: Oct 22 2015Oct 24 2015

Other

Other11th IEEE Biomedical Circuits and Systems Conference, BioCAS 2015
CountryUnited States
CityAtlanta
Period10/22/1510/24/15

ASJC Scopus subject areas

  • Biotechnology
  • Instrumentation
  • Biomedical Engineering
  • Electrical and Electronic Engineering

Fingerprint Dive into the research topics of 'Multi-function optogenetic stimulator and neural amplifier for wirelessly controlled neural interface'. Together they form a unique fingerprint.

  • Cite this

    Nag, S., Lee, P., Herikstad, R., Sng, J., Yen, S. C., & Thakor, N. V. (2015). Multi-function optogenetic stimulator and neural amplifier for wirelessly controlled neural interface. In IEEE Biomedical Circuits and Systems Conference: Engineering for Healthy Minds and Able Bodies, BioCAS 2015 - Proceedings [7348341] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/BioCAS.2015.7348341