Multi-component nanorods for vaccination applications

A. K. Salem; C. F. Hung; T. W. Kim; T. C. Wu; P. C. Searson; K. W. Leong

doi:10.1088/0957-4484/16/4/025

Multi-component nanorods for vaccination applications

A. K. Salem, C. F. Hung, T. W. Kim, T. C. Wu, P. C. Searson, K. W. Leong

School of Medicine

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

Immune responses from Au/Ni nanorods prepared by electrochemical deposition in alumina templates are evaluated in C57BL/6 mice. When the nanorods are bombarded into skin, they generate a strong CDS T-cell and antibody response. When pcDNA3 is bound to the Ni segment of the nanorod, it provides a strong immunostimulatory adjuvant effect to the antigen bound on the Au segment.

Original language	English (US)
Pages (from-to)	484-487
Number of pages	4
Journal	Nanotechnology
Volume	16
Issue number	4
DOIs	https://doi.org/10.1088/0957-4484/16/4/025
State	Published - Apr 2005

ASJC Scopus subject areas

Bioengineering
General Chemistry
General Materials Science
Mechanics of Materials
Mechanical Engineering
Electrical and Electronic Engineering

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10.1088/0957-4484/16/4/025

Cite this

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abstract = "Immune responses from Au/Ni nanorods prepared by electrochemical deposition in alumina templates are evaluated in C57BL/6 mice. When the nanorods are bombarded into skin, they generate a strong CDS T-cell and antibody response. When pcDNA3 is bound to the Ni segment of the nanorod, it provides a strong immunostimulatory adjuvant effect to the antigen bound on the Au segment.",

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AU - Hung, C. F.

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AU - Wu, T. C.

AU - Searson, P. C.

AU - Leong, K. W.

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AB - Immune responses from Au/Ni nanorods prepared by electrochemical deposition in alumina templates are evaluated in C57BL/6 mice. When the nanorods are bombarded into skin, they generate a strong CDS T-cell and antibody response. When pcDNA3 is bound to the Ni segment of the nanorod, it provides a strong immunostimulatory adjuvant effect to the antigen bound on the Au segment.

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Multi-component nanorods for vaccination applications

Abstract

ASJC Scopus subject areas

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