Abstract
Accurate quantitation of activity provides the basis for internal dosimetry of targeted radionuclide therapies. This study investigated quantitative imaging capabilities at sites with a variety of experience and equipment and assessed levels of errors in activity quantitation in Single-Photon Emission Computed Tomography (SPECT) and planar imaging. Participants from 9 countries took part in a comparison in which planar, SPECT and SPECT with X ray computed tomography (SPECT-CT) imaging were used to quantify activities of four epoxy-filled cylinders containing 133Ba, which was chosen as a surrogate for 131I. The sources, with nominal volumes of 2, 4, 6 and 23mL, were calibrated for 133Ba activity by the National Institute of Standards and Technology, but the activity was initially unknown to the participants. Imaging was performed in a cylindrical phantom filled with water. Two trials were carried out in which the participants first estimated the activities using their local standard protocols, and then repeated the measurements using a standardized acquisition and analysis protocol. Finally, processing of the imaging data from the second trial was repeated by a single centre using a fixed protocol. In the first trial, the activities were underestimated by about 15% with planar imaging. SPECT with Chang's first order attenuation correction (Chang-AC) and SPECT-CT overestimated the activity by about 10%. The second trial showed moderate improvements in accuracy and variability. Planar imaging was subject to methodological errors, e.g., in the use of a transmission scan for attenuation correction. The use of Chang-AC was subject to variability from the definition of phantom contours. The project demonstrated the need for training and standardized protocols to achieve good levels of quantitative accuracy and precision in a multicentre setting. Absolute quantification of simple objects with no background was possible with the strictest protocol to about 6% with planar imaging and SPECT (with Chang-AC) and within 2% for SPECT-CT. Eine genaue
| Original language | English (US) |
|---|---|
| Journal | Zeitschrift fur Medizinische Physik |
| DOIs | |
| State | Accepted/In press - Dec 4 2015 |
Fingerprint
Keywords
- Comparison
- Planar
- Planar
- Quantitative Bildgebung
- Quantitative imaging
- SPECT
- SPECT
- Vergleichsstudie
ASJC Scopus subject areas
- Biophysics
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology
Cite this
Multi-centre evaluation of accuracy and reproducibility of planar and SPECT image quantification : An IAEA phantom study. / Zimmerman, Brian E.; Grošev, Darko; Buvat, Irène; Coca Pérez, Marco A.; Frey, Eric; Green, Alan; Krisanachinda, Anchali; Lassmann, Michael; Ljungberg, Michael; Pozzo, Lorena; Quadir, Kamila Afroj; Terán Gretter, Mariella A.; Van Staden, Johann; Poli, Gian Luca.
In: Zeitschrift fur Medizinische Physik, 04.12.2015.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Multi-centre evaluation of accuracy and reproducibility of planar and SPECT image quantification
T2 - An IAEA phantom study
AU - Zimmerman, Brian E.
AU - Grošev, Darko
AU - Buvat, Irène
AU - Coca Pérez, Marco A.
AU - Frey, Eric
AU - Green, Alan
AU - Krisanachinda, Anchali
AU - Lassmann, Michael
AU - Ljungberg, Michael
AU - Pozzo, Lorena
AU - Quadir, Kamila Afroj
AU - Terán Gretter, Mariella A.
AU - Van Staden, Johann
AU - Poli, Gian Luca
PY - 2015/12/4
Y1 - 2015/12/4
N2 - Accurate quantitation of activity provides the basis for internal dosimetry of targeted radionuclide therapies. This study investigated quantitative imaging capabilities at sites with a variety of experience and equipment and assessed levels of errors in activity quantitation in Single-Photon Emission Computed Tomography (SPECT) and planar imaging. Participants from 9 countries took part in a comparison in which planar, SPECT and SPECT with X ray computed tomography (SPECT-CT) imaging were used to quantify activities of four epoxy-filled cylinders containing 133Ba, which was chosen as a surrogate for 131I. The sources, with nominal volumes of 2, 4, 6 and 23mL, were calibrated for 133Ba activity by the National Institute of Standards and Technology, but the activity was initially unknown to the participants. Imaging was performed in a cylindrical phantom filled with water. Two trials were carried out in which the participants first estimated the activities using their local standard protocols, and then repeated the measurements using a standardized acquisition and analysis protocol. Finally, processing of the imaging data from the second trial was repeated by a single centre using a fixed protocol. In the first trial, the activities were underestimated by about 15% with planar imaging. SPECT with Chang's first order attenuation correction (Chang-AC) and SPECT-CT overestimated the activity by about 10%. The second trial showed moderate improvements in accuracy and variability. Planar imaging was subject to methodological errors, e.g., in the use of a transmission scan for attenuation correction. The use of Chang-AC was subject to variability from the definition of phantom contours. The project demonstrated the need for training and standardized protocols to achieve good levels of quantitative accuracy and precision in a multicentre setting. Absolute quantification of simple objects with no background was possible with the strictest protocol to about 6% with planar imaging and SPECT (with Chang-AC) and within 2% for SPECT-CT. Eine genaue
AB - Accurate quantitation of activity provides the basis for internal dosimetry of targeted radionuclide therapies. This study investigated quantitative imaging capabilities at sites with a variety of experience and equipment and assessed levels of errors in activity quantitation in Single-Photon Emission Computed Tomography (SPECT) and planar imaging. Participants from 9 countries took part in a comparison in which planar, SPECT and SPECT with X ray computed tomography (SPECT-CT) imaging were used to quantify activities of four epoxy-filled cylinders containing 133Ba, which was chosen as a surrogate for 131I. The sources, with nominal volumes of 2, 4, 6 and 23mL, were calibrated for 133Ba activity by the National Institute of Standards and Technology, but the activity was initially unknown to the participants. Imaging was performed in a cylindrical phantom filled with water. Two trials were carried out in which the participants first estimated the activities using their local standard protocols, and then repeated the measurements using a standardized acquisition and analysis protocol. Finally, processing of the imaging data from the second trial was repeated by a single centre using a fixed protocol. In the first trial, the activities were underestimated by about 15% with planar imaging. SPECT with Chang's first order attenuation correction (Chang-AC) and SPECT-CT overestimated the activity by about 10%. The second trial showed moderate improvements in accuracy and variability. Planar imaging was subject to methodological errors, e.g., in the use of a transmission scan for attenuation correction. The use of Chang-AC was subject to variability from the definition of phantom contours. The project demonstrated the need for training and standardized protocols to achieve good levels of quantitative accuracy and precision in a multicentre setting. Absolute quantification of simple objects with no background was possible with the strictest protocol to about 6% with planar imaging and SPECT (with Chang-AC) and within 2% for SPECT-CT. Eine genaue
KW - Comparison
KW - Planar
KW - Planar
KW - Quantitative Bildgebung
KW - Quantitative imaging
KW - SPECT
KW - SPECT
KW - Vergleichsstudie
UR - http://www.scopus.com/inward/record.url?scp=84963811404&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84963811404&partnerID=8YFLogxK
U2 - 10.1016/j.zemedi.2016.03.008
DO - 10.1016/j.zemedi.2016.03.008
M3 - Article
C2 - 27105765
AN - SCOPUS:84963811404
JO - Zeitschrift fur Medizinische Physik
JF - Zeitschrift fur Medizinische Physik
SN - 0939-3889
ER -