Multi-Centre Comparison of Abbott Matrix® Aero™ to Pharmacia Standard Rast®, Modified Rast and Skin Puncture Tests

D. R. Ownby, N Franklin Adkinson, Robert G Hamilton, H. A. Homburger, H. J. Zeitz, D. Kowalski, R. E. Lindberg, P. M. Frank, L. Hrusovsky

Research output: Contribution to journalArticlepeer-review

Abstract

ABBOTT MATRIX® Aero™ is an enzyme immunoassay which measures specific IgE antibodies to 14 individually calibräted airborne allergens using a single serum specimen. In this study, ABBOTT MATRIX performance was evaluated in comparison to the results of skin puncture test and the Standard and Modified RAST® procedures. The ABBOTT MATRIX demonstrated overall sensitivity of 89% vs. Standard RAST and Modified RAST, with specificity greater than 92% vs. both methods. ABBOTT MATRIX sensitivity vs. skin test (71%) exceeded that of the Standard and Modified RAST procedures (62% and 67% respectively). Positive results reported by ABBOTT MATRIX but not RAST were corroborated by skin test results for 3 of 5 allergens evaluated. All in vitro Systems demonstrated specificity of approximately 90% vs. skin test. The ABBOTT MATRIX System provided results which compared favoräbly with the results of skin test and RAST, but required less hands-on time to obtain quantitative specific IgE measurements to multiple allergens.

Original languageEnglish (US)
Pages (from-to)631-638
Number of pages8
JournalClinical Chemistry and Laboratory Medicine
Volume32
Issue number8
DOIs
StatePublished - 1994
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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