Multi-atlas segmentation of the hydrocephalus brain using an adaptive ventricle atlas

Muhan Shao, Aaron Carass, Xiang Li, Blake E. Dewey, Ari M Blitz, Jerry Ladd Prince, Lotta M. Ellingsen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Normal pressure hydrocephalus (NPH) is a brain disorder caused by disruption of the flow of cerebrospinal fluid (CSF). The dementia-like symptoms of NPH are often mistakenly attributed to Alzheimer's disease. However, if correctly diagnosed, NPH patients can potentially be treated and their symptoms reversed through surgery. Observing the dilated ventricles through magnetic resonance imaging (MRI) is one element in diagnosing NPH. Diagnostic accuracy therefore benefits from accurate, automatic parcellation of the ventricular system into its sub-compartments. We present an improvement to a whole brain segmentation approach designed for subjects with enlarged and deformed ventricles. Our method incorporates an adaptive ventricle atlas from an NPH-atlas-based segmentation as a prior and uses a more robust relaxation scheme for the multi-atlas label fusion approach that accurately labels the four sub-compartments of the ventricular system. We validated our method on NPH patients, demonstrating improvement over state-of-the-art segmentation techniques.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2018
Subtitle of host publicationBiomedical Applications in Molecular, Structural, and Functional Imaging
PublisherSPIE
Volume10578
ISBN (Electronic)9781510616455
DOIs
StatePublished - Jan 1 2018
EventMedical Imaging 2018: Biomedical Applications in Molecular, Structural, and Functional Imaging - Houston, United States
Duration: Feb 11 2018Feb 13 2018

Other

OtherMedical Imaging 2018: Biomedical Applications in Molecular, Structural, and Functional Imaging
CountryUnited States
CityHouston
Period2/11/182/13/18

Keywords

  • enlarged brain ventricles
  • hydrocephalus
  • MRI
  • segmentation

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Multi-atlas segmentation of the hydrocephalus brain using an adaptive ventricle atlas'. Together they form a unique fingerprint.

Cite this