@inproceedings{2a973a5e221343979e9d0d6f35ed67aa,
title = "Multi-atlas segmentation of the hydrocephalus brain using an adaptive ventricle atlas",
abstract = "Normal pressure hydrocephalus (NPH) is a brain disorder caused by disruption of the flow of cerebrospinal fluid (CSF). The dementia-like symptoms of NPH are often mistakenly attributed to Alzheimer's disease. However, if correctly diagnosed, NPH patients can potentially be treated and their symptoms reversed through surgery. Observing the dilated ventricles through magnetic resonance imaging (MRI) is one element in diagnosing NPH. Diagnostic accuracy therefore benefits from accurate, automatic parcellation of the ventricular system into its sub-compartments. We present an improvement to a whole brain segmentation approach designed for subjects with enlarged and deformed ventricles. Our method incorporates an adaptive ventricle atlas from an NPH-atlas-based segmentation as a prior and uses a more robust relaxation scheme for the multi-atlas label fusion approach that accurately labels the four sub-compartments of the ventricular system. We validated our method on NPH patients, demonstrating improvement over state-of-the-art segmentation techniques.",
keywords = "MRI, enlarged brain ventricles, hydrocephalus, segmentation",
author = "Muhan Shao and Aaron Carass and Xiang Li and Dewey, {Blake E.} and Blitz, {Ari M.} and Prince, {Jerry L.} and Ellingsen, {Lotta M.}",
note = "Funding Information: This work was supported by the NIH/NINDS under grant R21-NS096497, the National Multiple Sclerosis Society grant RG-1507-05243, the Department of Defense in the Center for Neuroscience and Regenerative Medicine, and the Icelandic Centre for Research (RANNIS) under grant 173942051. Publisher Copyright: {\textcopyright} 2018 SPIE.; Medical Imaging 2018: Biomedical Applications in Molecular, Structural, and Functional Imaging ; Conference date: 11-02-2018 Through 13-02-2018",
year = "2018",
doi = "10.1117/12.2295613",
language = "English (US)",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Barjor Gimi and Andrzej Krol",
booktitle = "Medical Imaging 2018",
}