Mullerian Inhibiting Substance induces NFkB signaling in breast and prostate cancer cells

Yasunori Hoshiya; Vandana Gupta; Dorry L. Segev; Makiko Hoshiya; Jennifer L. Carey; Laura M. Sasur; Trinh T. Tran; Thanh U. Ha; Shyamala Maheswaran

doi:10.1016/j.mce.2003.09.010

Mullerian Inhibiting Substance induces NFkB signaling in breast and prostate cancer cells

Yasunori Hoshiya, Vandana Gupta, Dorry L. Segev, Makiko Hoshiya, Jennifer L. Carey, Laura M. Sasur, Trinh T. Tran, Thanh U. Ha, Shyamala Maheswaran

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

The MIS type II receptor is expressed at high levels in the Mullerian duct and in Sertoli cells and granulosa cells of the embryonic and adult gonads. The presence of MIS type II and type I receptors in tissues and cell lines derived from breast and prostate suggests that the prostate and mammary glands may be additional targets for MIS action. In both breast and prostate cancer cells, MIS activated NFkB DNA binding activity and induced IEX-1, an immediate early gene which regulates cell growth and apoptosis. Exposure of cells to MIS inhibited growth by increasing the fraction of cells in the G1 phase of the cell cycle and by inducing apoptosis. These results suggest that MIS may be a putative mediator of growth regulatory signals in the breast and prostate.

Original language	English (US)
Pages (from-to)	43-49
Number of pages	7
Journal	Molecular and Cellular Endocrinology
Volume	211
Issue number	1-2
DOIs	https://doi.org/10.1016/j.mce.2003.09.010
State	Published - Dec 15 2003
Externally published	Yes

Keywords

Breast
IEX-1
MIS
MIS type II receptor
NFkB
Prostate

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Endocrinology

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10.1016/j.mce.2003.09.010

Cite this

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title = "Mullerian Inhibiting Substance induces NFkB signaling in breast and prostate cancer cells",

abstract = "The MIS type II receptor is expressed at high levels in the Mullerian duct and in Sertoli cells and granulosa cells of the embryonic and adult gonads. The presence of MIS type II and type I receptors in tissues and cell lines derived from breast and prostate suggests that the prostate and mammary glands may be additional targets for MIS action. In both breast and prostate cancer cells, MIS activated NFkB DNA binding activity and induced IEX-1, an immediate early gene which regulates cell growth and apoptosis. Exposure of cells to MIS inhibited growth by increasing the fraction of cells in the G1 phase of the cell cycle and by inducing apoptosis. These results suggest that MIS may be a putative mediator of growth regulatory signals in the breast and prostate.",

keywords = "Breast, IEX-1, MIS, MIS type II receptor, NFkB, Prostate",

author = "Yasunori Hoshiya and Vandana Gupta and Segev, {Dorry L.} and Makiko Hoshiya and Carey, {Jennifer L.} and Sasur, {Laura M.} and Tran, {Trinh T.} and Ha, {Thanh U.} and Shyamala Maheswaran",

note = "Funding Information: We thank Drs. Patricia K. Donahoe and David T. MacLaughlin for their support of this work. This work was supported by the Surdna fellowship fund from the Department of Surgery, Massachusetts General Hospital (to YH) and by the Breast Cancer Research Grant from the Massachusetts Department of Public Health, the Avon Breast Cancer Pilot Project Grant, the Claflin Distinguished Scholar Award, partial support from the Dana-Farber Harvard Breast Cancer SPORE, the Hershey Family Foundation and Survivors walk for Prostate Cancer and from NIH/NCI grant CA89138-01A1 (to SM).",

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doi = "10.1016/j.mce.2003.09.010",

language = "English (US)",

volume = "211",

pages = "43--49",

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T1 - Mullerian Inhibiting Substance induces NFkB signaling in breast and prostate cancer cells

AU - Hoshiya, Yasunori

AU - Gupta, Vandana

AU - Segev, Dorry L.

AU - Hoshiya, Makiko

AU - Carey, Jennifer L.

AU - Sasur, Laura M.

AU - Tran, Trinh T.

AU - Ha, Thanh U.

AU - Maheswaran, Shyamala

N1 - Funding Information: We thank Drs. Patricia K. Donahoe and David T. MacLaughlin for their support of this work. This work was supported by the Surdna fellowship fund from the Department of Surgery, Massachusetts General Hospital (to YH) and by the Breast Cancer Research Grant from the Massachusetts Department of Public Health, the Avon Breast Cancer Pilot Project Grant, the Claflin Distinguished Scholar Award, partial support from the Dana-Farber Harvard Breast Cancer SPORE, the Hershey Family Foundation and Survivors walk for Prostate Cancer and from NIH/NCI grant CA89138-01A1 (to SM).

PY - 2003/12/15

Y1 - 2003/12/15

N2 - The MIS type II receptor is expressed at high levels in the Mullerian duct and in Sertoli cells and granulosa cells of the embryonic and adult gonads. The presence of MIS type II and type I receptors in tissues and cell lines derived from breast and prostate suggests that the prostate and mammary glands may be additional targets for MIS action. In both breast and prostate cancer cells, MIS activated NFkB DNA binding activity and induced IEX-1, an immediate early gene which regulates cell growth and apoptosis. Exposure of cells to MIS inhibited growth by increasing the fraction of cells in the G1 phase of the cell cycle and by inducing apoptosis. These results suggest that MIS may be a putative mediator of growth regulatory signals in the breast and prostate.

AB - The MIS type II receptor is expressed at high levels in the Mullerian duct and in Sertoli cells and granulosa cells of the embryonic and adult gonads. The presence of MIS type II and type I receptors in tissues and cell lines derived from breast and prostate suggests that the prostate and mammary glands may be additional targets for MIS action. In both breast and prostate cancer cells, MIS activated NFkB DNA binding activity and induced IEX-1, an immediate early gene which regulates cell growth and apoptosis. Exposure of cells to MIS inhibited growth by increasing the fraction of cells in the G1 phase of the cell cycle and by inducing apoptosis. These results suggest that MIS may be a putative mediator of growth regulatory signals in the breast and prostate.

KW - Breast

KW - IEX-1

KW - MIS

KW - MIS type II receptor

KW - NFkB

KW - Prostate

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Mullerian Inhibiting Substance induces NFkB signaling in breast and prostate cancer cells

Abstract

Keywords

ASJC Scopus subject areas

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