Mullerian agenesis associated with in-utero thalidomide exposure: A case report

Sarah Dotters-Katz, Lisa C. Muasher, Suheil J. Muasher

Research output: Contribution to journalArticle

Abstract

Thalidomide is a well-known teratogen, which is experiencing resurgence as new uses are identified. Exposure is classically associated with limb deformities, such as: dysmelia, phocomelia, preaxial hypoplasia and polydactyly, in addition to visceral anomalies that have been documented as well. We report a case of a 38 year-old nulligravid female, who was previously evaluated for primary amenorrhea, and given the presumptive false diagnosis of an imperforate hymen. On magnetic resonance imaging (MRI) exam, she was noted to have uterovaginal agenesis. The implications of thalidomide on women's health extend beyond external birth defects. Although, most commonly associated with limb deformities, there may also be gynecologic implications of in utero exposure. As this medication is increasingly used for various medical conditions, obstetricians/gynecologists need to remain aware of this potential mullerian teratogenic effect.

Original languageEnglish (US)
Pages (from-to)214-216
Number of pages3
JournalMiddle East Fertility Society Journal
Volume18
Issue number3
DOIs
StatePublished - Sep 2013
Externally publishedYes

Fingerprint

Thalidomide
Extremities
Ectromelia
Polydactyly
Teratogens
Amenorrhea
Women's Health
Magnetic Resonance Imaging
Imperforate Hymen

Keywords

  • In utero exposure
  • Mullerian agenesis
  • Teratogen
  • Thalidomide

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Mullerian agenesis associated with in-utero thalidomide exposure : A case report. / Dotters-Katz, Sarah; Muasher, Lisa C.; Muasher, Suheil J.

In: Middle East Fertility Society Journal, Vol. 18, No. 3, 09.2013, p. 214-216.

Research output: Contribution to journalArticle

Dotters-Katz, Sarah ; Muasher, Lisa C. ; Muasher, Suheil J. / Mullerian agenesis associated with in-utero thalidomide exposure : A case report. In: Middle East Fertility Society Journal. 2013 ; Vol. 18, No. 3. pp. 214-216.
@article{344ba1fbec7a412187fd0485bbfaa4b6,
title = "Mullerian agenesis associated with in-utero thalidomide exposure: A case report",
abstract = "Thalidomide is a well-known teratogen, which is experiencing resurgence as new uses are identified. Exposure is classically associated with limb deformities, such as: dysmelia, phocomelia, preaxial hypoplasia and polydactyly, in addition to visceral anomalies that have been documented as well. We report a case of a 38 year-old nulligravid female, who was previously evaluated for primary amenorrhea, and given the presumptive false diagnosis of an imperforate hymen. On magnetic resonance imaging (MRI) exam, she was noted to have uterovaginal agenesis. The implications of thalidomide on women's health extend beyond external birth defects. Although, most commonly associated with limb deformities, there may also be gynecologic implications of in utero exposure. As this medication is increasingly used for various medical conditions, obstetricians/gynecologists need to remain aware of this potential mullerian teratogenic effect.",
keywords = "In utero exposure, Mullerian agenesis, Teratogen, Thalidomide",
author = "Sarah Dotters-Katz and Muasher, {Lisa C.} and Muasher, {Suheil J.}",
year = "2013",
month = "9",
doi = "10.1016/j.mefs.2013.01.007",
language = "English (US)",
volume = "18",
pages = "214--216",
journal = "Middle East Fertility Society Journal",
issn = "1110-5690",
publisher = "Middle East Fertility Society",
number = "3",

}

TY - JOUR

T1 - Mullerian agenesis associated with in-utero thalidomide exposure

T2 - A case report

AU - Dotters-Katz, Sarah

AU - Muasher, Lisa C.

AU - Muasher, Suheil J.

PY - 2013/9

Y1 - 2013/9

N2 - Thalidomide is a well-known teratogen, which is experiencing resurgence as new uses are identified. Exposure is classically associated with limb deformities, such as: dysmelia, phocomelia, preaxial hypoplasia and polydactyly, in addition to visceral anomalies that have been documented as well. We report a case of a 38 year-old nulligravid female, who was previously evaluated for primary amenorrhea, and given the presumptive false diagnosis of an imperforate hymen. On magnetic resonance imaging (MRI) exam, she was noted to have uterovaginal agenesis. The implications of thalidomide on women's health extend beyond external birth defects. Although, most commonly associated with limb deformities, there may also be gynecologic implications of in utero exposure. As this medication is increasingly used for various medical conditions, obstetricians/gynecologists need to remain aware of this potential mullerian teratogenic effect.

AB - Thalidomide is a well-known teratogen, which is experiencing resurgence as new uses are identified. Exposure is classically associated with limb deformities, such as: dysmelia, phocomelia, preaxial hypoplasia and polydactyly, in addition to visceral anomalies that have been documented as well. We report a case of a 38 year-old nulligravid female, who was previously evaluated for primary amenorrhea, and given the presumptive false diagnosis of an imperforate hymen. On magnetic resonance imaging (MRI) exam, she was noted to have uterovaginal agenesis. The implications of thalidomide on women's health extend beyond external birth defects. Although, most commonly associated with limb deformities, there may also be gynecologic implications of in utero exposure. As this medication is increasingly used for various medical conditions, obstetricians/gynecologists need to remain aware of this potential mullerian teratogenic effect.

KW - In utero exposure

KW - Mullerian agenesis

KW - Teratogen

KW - Thalidomide

UR - http://www.scopus.com/inward/record.url?scp=84882812235&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84882812235&partnerID=8YFLogxK

U2 - 10.1016/j.mefs.2013.01.007

DO - 10.1016/j.mefs.2013.01.007

M3 - Article

AN - SCOPUS:84882812235

VL - 18

SP - 214

EP - 216

JO - Middle East Fertility Society Journal

JF - Middle East Fertility Society Journal

SN - 1110-5690

IS - 3

ER -