Mullerian agenesis associated with in-utero thalidomide exposure: A case report

Sarah Dotters-Katz, Lisa C. Muasher, Suheil J. Muasher

Research output: Contribution to journalArticlepeer-review


Thalidomide is a well-known teratogen, which is experiencing resurgence as new uses are identified. Exposure is classically associated with limb deformities, such as: dysmelia, phocomelia, preaxial hypoplasia and polydactyly, in addition to visceral anomalies that have been documented as well. We report a case of a 38 year-old nulligravid female, who was previously evaluated for primary amenorrhea, and given the presumptive false diagnosis of an imperforate hymen. On magnetic resonance imaging (MRI) exam, she was noted to have uterovaginal agenesis. The implications of thalidomide on women's health extend beyond external birth defects. Although, most commonly associated with limb deformities, there may also be gynecologic implications of in utero exposure. As this medication is increasingly used for various medical conditions, obstetricians/gynecologists need to remain aware of this potential mullerian teratogenic effect.

Original languageEnglish (US)
Pages (from-to)214-216
Number of pages3
JournalMiddle East Fertility Society Journal
Issue number3
StatePublished - Sep 2013


  • In utero exposure
  • Mullerian agenesis
  • Teratogen
  • Thalidomide

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


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